Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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REVIEW ARTICLE
Year : 2020  |  Volume : 151  |  Issue : 1  |  Page : 22-34

The need & the issues related to new-generation typhoid conjugate vaccines in India


1 Mangla Hospital & Research Center, Bijnor, Uttar Pradesh, India
2 Department of Pediatrics, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India

Correspondence Address:
Dr Vipin M Vashishtha
Mangla Hospital & Research Center, Shakti Chowk, Bijnor 246 701, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_1890_17

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The low- and middle-income countries bear the highest burden of typhoid fever in the world. India, along with other South Asian countries, has a significant incidence of typhoid fever among young children though there is a paucity of published data on community burden. In spite of the availability of Vi-polysaccharide (Vi-PS) and conjugated Vi-PS vaccines, these are not adequately utilized in India and in the neighbouring countries. To address many shortcomings of the unconjugated Vi-PS vaccines, typhoid conjugate vaccines (TCVs) are developed by conjugating Vi-PS with different carrier proteins. Three such vaccines using tetanus toxoid as a carrier protein are already licensed in India. Several other Vi-PS conjugates are currently in various stages of development. The current review provides an update on the existing and upcoming new TCVs along with a detailed discussion on the various issues involved with their clinical use and limitations.


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