Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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REVIEW ARTICLE
Year : 2019  |  Volume : 150  |  Issue : 6  |  Page : 532-545

Environmental & occupational exposure & female reproductive dysfunction


Division of Reproductive & Cyto-toxicology, ICMR-National Institute of Occupational Health, Ahmedabad, Gujarat, India

Correspondence Address:
Dr Sunil Kumar
Division of Reproductive & Cyto-toxicology, ICMR-National Institute of Occupational Health, Meghani Nagar, Ahmedabad 380 016, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_1652_17

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All individuals are exposed to certain chemical, physical, biological, environmental as well as occupational factors. The data pertaining to role of these factors on female reproduction are scanty as compared to male. The available data suggest the adverse effects of certain toxicants, viz., metals such as lead, cadmium and mercury, pesticides such as bis(4-chlorophenyl)-1,1,1-trichloroethane and organic solvent such as benzene, toluene and ionizing radiation on the female reproductive system affecting directly the organ system or impacting in directly through hormonal impairments, molecular alterations, oxidative stress and DNA methylation impairing fertility as well as pregnancy and its outcomes. Thus, there is a need for awareness and prevention programme about the adverse effects of these factors and deterioration of female reproductive health, pregnancy outcome and offspring development as some of these chemicals might affect the developing foetus at very low doses by endocrine disruptive mechanism.


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