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REVIEW ARTICLE
Year : 2019  |  Volume : 150  |  Issue : 4  |  Page : 345-358

The human gut resistome: Current concepts & future prospects


1 Department of Medical Microbiology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
2 Department of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India

Correspondence Address:
Dr Neelam Taneja
Department of Medical Microbiology, 2nd Floor, Research Block A, Postgraduate Institute of Medical Education & Research, Sector 12, Chandigarh 160 012
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_1979_17

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The human gut is home to a myriad of organisms. While some are harmless commensals, others are transient, pathogenic flora. The gut microbiome is composed of diverse bacterial flora, and apart from playing a major role in protecting from various infectious and non-infectious diseases, it plays an important role in resistance to antimicrobials. The collection of genes or genetic material that confers antimicrobial resistance constitutes the gut resistome, and it may involve the pathogens or commensals of the intestinal tract. The diversity of this gut resistome is influenced by various environmental factors including the diet and antibiotic exposure. This review highlights the recent concepts pertaining to the human gut resistome, factors affecting it, how it impacts human health and diseases, methods to study the resistome and potential therapeutic approaches.


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