Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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REVIEW ARTICLE
Year : 2019  |  Volume : 150  |  Issue : 1  |  Page : 23-32

Adhesion molecules facilitate host-pathogen interaction & mediate Mycobacterium tuberculosis pathogenesis


Allergy & Infectious Diseases, CSIR-Institute of Genomics & Integrative Biology, Delhi, India

Correspondence Address:
Dr Laxman S Meena
CSIR-Institute of Genomics & Integrative Biology, Mall Road, Delhi 110 007
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_2055_16

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Most of the microorganisms display adhesion molecules on their surface which help them to bind and interact with the host cell during infection. Adhesion molecules help mycobacteria to colonize and invade immune system of the host, and also trigger immune response explicated by the host against the infection. Hence, understanding the signalling pathways illustrated by these molecules to enhance our knowledge on mycobacterial survival and persistence inside the host cell is required. Hence, this review was focussed on the role of adhesion molecules and their receptor molecules. The various mechanisms adopted by adhesion molecules to bind with the specific receptors on the host cell and their role in invasion and persistence of mycobacterium inside the host cell are explained.


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