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ORIGINAL ARTICLE
Year : 2019  |  Volume : 149  |  Issue : 4  |  Page : 544-547

Plasma ghrelin levels after laparoscopic sleeve gastrectomy in obese individuals


1 Department of Physiology, Dayanand Medical College & Hospital, Ludhiana, India
2 Department of Surgery, Dayanand Medical College & Hospital, Ludhiana, India
3 Department of Gastrointestinal Surgery, Amrita Institute of Medical Sciences & Research, Kochi, India
4 Department of Community Medicine, Dayanand Medical College & Hospital, Ludhiana, India

Correspondence Address:
Dr Garima Sharma
Department of Physiology, Dayanand Medical College & Hospital, Civil Lines, Ludhiana 141 001, Punjab
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_984_18

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Background & objectives: Ghrelin is an orexigenic gut hormone expressed by the gastric fundus. Laparoscopic sleeve gastrectomy (LSG) procedure involves resection of the gastric fundus leading to a decreased appetite and weight loss. This study was undertaken to determine the levels of plasma ghrelin after sleeve gastrectomy in obese patients. Methods: The study was conducted on 90 morbidly obese patients [body mass index (BMI) >40 kg/m[2]] and severely obese patients (BMI >35/kg/m[2]) who underwent sleeve gastrectomy. The patients were followed up for six months. Weight loss parameters and plasma ghrelin levels were assessed pre- and postoperatively. Results: A significant weight loss and decrease in BMI were observed at three and six months postoperatively. A significant decrease in plasma ghrelin levels over six months of follow up postoperatively was also seen. Interpretation & conclusions: These preliminary findings indicated inhibition of ghrelin production after LSG leading to a decrease in the plasma ghrelin levels within a few days of surgery and sustainable weight loss in obese patients.


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