|Year : 2018 | Volume
| Issue : 5 | Page : 531-538
Are excess carbohydrates the main link to diabetes & its complications in Asians?
Viswanathan Mohan1, Ranjit Unnikrishnan1, S Shobana2, M Malavika2, RM Anjana1, V Sudha2
1 Department of Diabetology, Dr Mohan's Diabetes Specialities Centre & Madras Diabetes Research Foundation, Chennai, India
2 Department of Foods Nutrition & Dietetics Research, Madras Diabetes Research Foundation, Chennai, India
|Date of Submission||10-Sep-2018|
|Date of Web Publication||21-Jan-2019|
Dr Viswanathan Mohan
Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, Dr Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Disease Prevention & Control & IDF Centre of Excellence in Diabetes Care, No. 4, Conran Smith Road, Gopalapuram, Chennai 600 086, Tamil Nadu
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Dietary carbohydrates form the major source of energy in Asian diets. The carbohydrate quantity and quality play a vital function in the prevention and management of diabetes. High glycaemic index foods elicit higher glycaemic and insulinaemic responses and promote insulin resistance and type 2 diabetes (T2D) through beta-cell exhaustion. This article reviews the evidence associating dietary carbohydrates to the prevalence and incidence of T2D and metabolic syndrome (MS) in control of diabetes and their role in the complications of diabetes. Cross-sectional and longitudinal studies show that higher carbohydrate diets are linked to higher prevalence and incidence of T2D. However, the association seems to be stronger in Asian-Indians consuming diets high in carbohydrates and more marked on a background of obesity. There is also evidence for high carbohydrate diets and risk for MS and cardiovascular disease (CVD). However, the quality of carbohydrates is also equally important. Complex carbohydrates such as brown rice, whole wheat bread, legumes, pulses and green leafy vegetables are good carbs. Conversely, highly polished rice or refined wheat, sugar, glucose, highly processed foods such as cookies and pastries, fruit juice and sweetened beverages and fried potatoes or French fries are obviously 'bad' carbs. Ultimately, it is all a matter of balance and moderation in diet. For Indians who currently consume about 65-75 per cent of calories from carbohydrates, reducing this to 50-55 per cent and adding enough protein (20-25%) especially from vegetable sources and the rest from fat (20-30%) by including monounsaturated fats (e.g. groundnut or mustard oil, nuts and seeds) along with a plenty of green leafy vegetables, would be the best diet prescription for the prevention and management of non-communicable diseases such as T2D and CVD.
Keywords: Bad carbs - carbohydrates - complications - diet - glycaemic index - glycaemic load - good carbs - incidence - prevalence - type 2 diabetes
|How to cite this article:|
Mohan V, Unnikrishnan R, Shobana S, Malavika M, Anjana R M, Sudha V. Are excess carbohydrates the main link to diabetes & its complications in Asians?. Indian J Med Res 2018;148:531-8
|How to cite this URL:|
Mohan V, Unnikrishnan R, Shobana S, Malavika M, Anjana R M, Sudha V. Are excess carbohydrates the main link to diabetes & its complications in Asians?. Indian J Med Res [serial online] 2018 [cited 2019 Dec 9];148:531-8. Available from: http://www.ijmr.org.in/text.asp?2018/148/5/531/249973
| Introduction|| |
The prevalence of type 2 diabetes (T2D) is increasing at exponential rates. In 2017, it was estimated that there were almost 425 million individuals affected with diabetes and this number is likely to rise to 629 million by 20451. Seventy five per cent of people with diabetes reside in low- and middle-income countries. There were an estimated five million deaths attributable to diabetes in 20151. The overall prevalence of diabetes in India, based on a study of 15 whole States of India, was 7.3 per cent. Asian-Indians have higher predilection to T2D and this is due to the 'Asian-Indian phenotype' which includes features such as central body obesity, insulin resistance (IR), higher insulin, triglyceride levels and low high-density lipoprotein (HDL) cholesterol levels. In addition, physical activity levels are markedly low in India. There have also been rapid changes in the dietary composition of Asian-Indians such that diets today are high in refined carbohydrates, sugars, fats and salt. All these factors contribute to the rising prevalence of diabetes, hypertension and cardiovascular diseases (CVDs).
The three major proximate principles in the diet are carbohydrate, protein and fat. Restriction of any one of these components will have to be made up by increasing the proportion of calories derived from the other two. Since the protein content of Indian diets can rarely be increased above 20-25 per cent, especially in vegetarians, diets can be characterized as either 'high-carbohydrate' or 'high fat', or a diet containing combination of the two in equalproportions.
| What are carbohydrates?|| |
Carbohydrates are compounds containing carbon, hydrogen and oxygen. These are digested or metabolically converted directly into glucose or oxidized into pyruvate. Carbohydrates can be categorized as monosaccharides, disaccharides, oligosaccharides and polysaccharides (starch) depending on the degree of polymerization. It is important to consider the physiological basis [as measured by glycaemic index (GI)] of carbohydrate classification rather than its chemical classification into simple and complex carbohydrates (based on their chain length). Carbohydrate is the chief source of energy in many low- and middle-income countries, contributing up to 70-80 per cent of daily calories. Diets of Asian countries including India continue to derive two-thirds of carbohydrate calories from cereal staples and this has not changed during the last three decades in India,.
This review mainly focuses on the effect of carbohydrates on the risk for development of diabetes as well as its role in prevention and management and finally its role in diabetes complications.
| Carbohydrates & the prevalence of diabetes|| |
The dietary carbohydrate's quantity and also the quality are found to be linked to the prevalence of diabetes in many parts of the globe. Gross et al reported from ecological assessments that the US has witnessed huge surges in the rates of obesity in the 20th century not only in adults but also in children. Their study further suggested that there was a profound shift in the quality of carbohydrates from whole grain-based diets in the first decade of 20th century to refined carbohydrates through processed foods such as corn syrup by the end of 20th century. This resulted in decreased dietary fibre content of the American diets which was associated with the increased prevalence of not only T2D but also obesity. The higher levels of fructose in the corn syrup were linked to metabolic syndrome (MS) and also IR, especially in the US10.
The prevalence rates of diabetes in India have been increasing steeply. Secular trend studies have reported that the urban regions of India experienced a ten-fold increase in the prevalence of diabetes over a 40 years period (2.3% in 197111 as against 22.8% in 201412). During the last decade, the prevalence of diabetes in metropolitan cities in Chennai and Delhi increased by almost 30 per cent every four years from 14.3 to 18.6 per cent and 22.8 per cent,,,. Mohan et al reported that in Asian-Indians from the urban regions of south India, the dietary carbohydrate and glycaemic load (GL) were linked to increased, dietary fibre intake to decreased, risk of T2D in the Chennai Urban Rural Epidemiological Study. The predominant intake of carbohydrates from polished grains in Indian diets also means that they are low in other healthy carbohydrate foods such as whole grains, fruits and vegetables,.
Both dietary GL and GI have been correlated with several metabolic risk parameters in Japanese female farmers with traditional dietary habits. Rice predominantly contributes to the total carbohydrates and energy intake in this population and in that respect differs from the western populations. Dietary GI was positively correlated with fasting glucose and triacylglycerol, body mass index (BMI), and glycated haemoglobin (HbA1c), while dietary GL was positively correlated with fasting glucose and triacylglycerol and negatively correlated with HDL cholesterol. The GI and GL, primarily determined from white rice (WR), were independently correlated with several metabolic risk parameters.
| Carbohydrates & the incidence of diabetes|| |
A prospective cohort of the Nurses' Health Study that followed US women for nearly 24 yr had shown that diets with higher starch-to-cereal fibre ratio and lower fibre intake were associated with increased risk for incident cases of T2D18. It was reported that, when the first and fifth quintiles were compared, starch intake was associated with a greater risk of T2D [relative risk (RR)=1.23], whereas total fibre (RR=0.80), cereal fibre (RR=0.71) and fruit fibre (RR=0.79) intakes were associated with a lesser risk of T2D. They suggested the starch-to-cereal fibre ratio of the diet as a novel parameter for evaluating the carbohydrate quality in association to T2D. Diets with higher refined carbohydrate content and sugar- sweetened beverages have higher carbohydrate-to-fibre ratio. Hence, the American Heart Association recommends foods with carbohydrate-to-fibre ratio of not higher than 10:1.
Sakurai et al in their cohort study evaluated the risk for developing T2D in Japanese men, based on the percentage of energy intake contributed by carbohydrates and the level of obesity. They reported that higher carbohydrate intake was linked with an increased risk for new-onset T2D in obese individuals rather than in non-obese individuals. They also recommended that obese participants with increased carbohydrate intake (>65% energy) to restrict their intakes within 50-65 per cent energy to prevent T2D. The authors reported a significantly higher hazard ratio (2.01) for diabetes among obese participants with higher carbohydrates intake (>65% energy) than those with lower carbohydrates intake (50-57%).
In urban Indians in Chennai (10 yr follow up study), Anjana et al showed that higher diet risk score which included larger intake of refined grains and reduced intake of vegetables and fruits, dairy and nuts doubled the incidence of new-onset T2D.
Hu et al in their systematic review on WR intake and risk for T2D reported that increased consumption of WR was linked with a higher risk of T2D in Japanese and Chinese population. They further indicated that the association between WR consumption and T2D was stronger for Asian population as compared to the western population. In the dose-response analysis, it was shown that for each extra serving of WR, there was an 11 per cent increase in risk for diabetes. Conversely, Sun et al showed that brown rice (BR, unpolished rice) intake was linked with a lower risk for diabetes in a western population. Zhang et al however, showed that substituting WR with BR for a duration of 16 wk did not alter the metabolic risk parameters in Chinese population at increased diabetes risk, although they reported higher HDL cholesterol and lower diastolic blood pressure (BP) in those who consumed BR. Probably, the substitution with BR needs to be maintained for much longer duration of time to alter the risk of T2D.
Villegas et al, in a cohort study conducted in Chinese women, reported positive links between dietary carbohydrate intake, GI and GL, and the incidence of T2D and a stronger association was observed between the intake of WR and the risk of developing T2D.
| Carbohydrates & metabolic syndrome|| |
The term MS refers to a clustering of metabolic abnormalities including central obesity, dyslipidaemia, glucose intolerance and hypertension. Individuals with MS have a higher risk for CVD and five-fold higher risk for T2D26. Radhika et al showed that larger intake of refined grains was associated with IR and MS in Asian-Indians who regularly consumed diets containing higher levels of carbohydrate. With increased quintiles of refined grain intake, increased metabolic abnormalities such as body weight, waist circumference, IR, BP, triglycerides and fasting blood glucose were observed, along with lower levels of HDL cholesterol. In this population, WR was the major contributor of the refined grains (≈76%) with an average intake of 253 g/day and this was linked with an eight-fold increase for the risk of MS27.
Recently, Park et al evaluated whether carbohydrate and/or fatty acid intake modified the prevalence of MS and found that high carbohydrate diets (≈74% E) irrespective of fatty acid composition were positively associated with MS in Korean women. A stronger association for higher incidence of IR and higher dietary GL was reported in the Framingham Offspring Study cohort and with dyslipidaemia and coronary heart disease (CHD),. McKeown et al reported that whole grains, cereal fibre, total dietary fibre and fruit were inversely, and GL and GI were positively, associated with homeostasis model assessment-insulin resistance (HOMA-IR). These studies clearly underscore the significance of whole grain-based, low GI diets in the prevention of MS. One study from south India showed that the prevalence of MS was higher in sunflower oil consumers (30.7%) and was further worsened by the quantity of polished cereals consumed. The authors concluded that the oils rich in PUFA such as sunflower oil could aggravate the risk for MS, particularly in Asian-Indian population who regularly consume diets containing higher levels of refined grains and with low intakes of alpha-linolenic acid. Obviously, the role of dietary factors is multifactorial and these do not act in isolation.
| Carbohydrate & control of diabetes|| |
Postprandial hyperglycaemia is an important factor in the control of diabetes. Both the quantity and type of carbohydrate could affect insulin secretion and postprandial glycaemia. Shadman et al evaluated the macronutrient distribution and its effect on glycaemic control among individuals with T2D consuming high calories and showed that 25 kcal from carbohydrates/kg body weight was inversely, and 30 kcals of fat/kg body weight positively, associated with HbA1c levels after adjusting for potential confounders. The same study has shown that the substitution of fat for carbohydrates reduced HbA1c levels. However, a critical review that looked at the effect of different carbohydrate diets in individuals with T2D indicated that low carbohydrate diets (LCDs, <45% E) were no different from the high carbohydrate diets with regards to metabolic markers and glycaemic control. The study however commented that LCDs might not have been sustainable in the longer term as most studies used diets containing moderate levels of carbohydrate. Mayer et al analyzed participants with T2D in a weight loss trial who were randomized to 48 wk of either a LCD or to a low-fat diet with orlistat. They showed that although both the interventions decreased the BMI, LCD showed better improvement in HbA1c and also led to a greater decrease in anti-glycaemic medications. This was attributed to the reduction in carbohydrate quantity, GI and/or greater improvement in insulin sensitivity. Increasing the dietary fibre content of diets by increasing the vegetable intake and inclusion of low GI carbohydrates may also be helpful in achieving better glycaemic control. A recent systematic review and meta-analysis on carbohydrate restriction in T2D revealed that, in the short term, LCDs containing less than 45 per cent energy had better effect on glycaemic control than high carbohydrate diets. However, no differences existed between LCDs and high carbohydrate diets in the long term on glycaemic control, possibly due to the difficulty in sustaining LCDs for a long time. This analysis also indicated that similar benefits were observed on quality of life, weight gain, low-density lipoprotein cholesterol and between isocaloric diets, LCDs and high carbohydrate diets.
Another randomized crossover trial over a one-year period demonstrated similar beneficial effects on glycaemic markers for both high-monounsaturated fatty acid (MUFA) and high carbohydrate diets in which the total energy intake was controlled, suggesting that a variety of diets may benefit individuals with diabetes and that the total calories are probably more important.
| Carbohydrate & remission of diabetes|| |
The Diabetes Prevention Programme (DPP) and ACTNOW studies suggest that the rate of conversion of impaired glucose tolerance (IGT) to T2D was almost 7-10 per cent per year and that the primary driver of the conversion to T2D was obesity. Obesity increases the risk for health diseases and lifestyle intervention such as weight loss and physical activity reduced the risk for diabetes by almost 58 per cent. Stentz et al reported 100 per cent remission of pre-diabetes to normal glucose levels in adults with obesity with a high protein diet as compared to only 33 per cent remission which was observed with a diet high in carbohydrate. The high protein diet group had greater insulin sensitivity, greater reduction in diabetogenic risk factors and less inflammation and oxidative stress than the high carbohydrate diet group. Moreover, lean body mass percentage increased, while fat mass percentage decreased. Apart from inclusion of lean meat, fish, chicken and egg white, inclusion of legumes and pulses could help in increasing the protein content of diets in vegetarians.
Weber et al reported on the 'Diabetes Community Lifestyle Improvement Program', translation trial (a randomized, controlled) rendered in Asian-Indian overweight/obese adults in Chennai with isolated IGT, isolated impaired fasting glucose (IFG) or combined IFG+IGT. The participants were randomized to a standard lifestyle advice (control, standard of care for pre-diabetes: one day visit to a physician, a dietitian, fitness trainer and a one-day group class focusing on diabetes prevention which advocated a diet rich in complex carbohydrate and with lower fat content, inclusion of fruits and vegetables and increasing exercise). The intervention group followed a culturally tailored, U.S. DPP-based lifestyle curriculum for duration of six months which included diet training to reduce dietary intake by maintaining weekly food diaries on weekly basis, adhering to individualized goals for carbohydrate restriction, portion size reduction and increasing fiber-rich food intake. In addition, metformin was added for participants who did not respond to lifestyle modification after a follow up of four months. The incidence of diabetes was assessed twice a year and compared between the two groups. This study showed that customized tailoring of diet with special reference to both quantity and quality of carbohydrate along with increasing physical activity can help in the prevention of diabetes.
| Carbohydrates & complications of diabetes|| |
Chronic complications of diabetes include micro-angiopathy (retinopathy, nephropathy and neuropathy) and macro-angiopathy (ischaemic heart disease, cerebrovascular disease and peripheral vascular disease). Through postprandial hyperglycaemia, high GI carbohydrates and high GL diets may mediate the risk of these complications. Juraschek et al reported on the effect of the type of carbohydrate on kidney function. Overweight or obese adults with no diabetes or kidney diseases were provided with each of four isocaloric diets (in a randomized crossover design) namely high GI (≥65) with higher carbohydrate percentage (58% kcal) reference diet, low GI (≤45) with low percentage carbohydrate (40% kcal), low GI with high percentage carbohydrate and high GI with low percentage carbohydrate. The LCDs had higher per cent protein. The results indicated that reducing the GI and the percentage carbohydrate and increasing the protein and fat calories increased the glomerular filtration rate and improved biomarkers of renal disease. Another group studied the effect of GI and GL of carbohydrates on the risk for CVD43. Overweight or obese adults were assigned either to one of the four diets with reduced-fat and high-fibre content for a duration of 12 wk. First two diets had higher carbohydrate content (55% of total energy intake), with either high or low GIs, third and fourth diets had higher protein content (25% of total energy intake), with high or low GIs. The GL was highest in the first diet and lowest in the fourth diet. They concluded that both high-protein and low-GI regimens increased body fat loss. However, cardiovascular risk reduction was optimized by a high-carbohydrate, low-GI diet. This emphasizes the role of carbohydrate quality in mediating risk for CVD.
Jenkins et al studied T2D participants who were on either a low-GI legume diet or a diet with higher insoluble fibre from wheat based products for three months. They showed that the HbA1c values were reduced by 0.5 per cent in the low-GI legume diet as compared to the high wheat fibre diet (-0.3%). The CHD risk reduction in the low-GI legume diet (-0.8%) was attributed to the higher relative reduction in systolic blood pressure in this group as compared to the high wheat fibre diet. Thus, inclusion of wholegrain legumes in the diets not only improves the protein and dietary fibre intake but also improves the glycaemic properties of the diet and thus help in CHD risk reduction in patients with T2D.
| Carbohydrates & mortality|| |
Dehghan et al recently reported on the results of the Prospective Urban and Rural Epidemiological (PURE) study conducted on 135,335 individuals aged 35-70 yr (enrolled between 2003 and 2013) in almost 18 countries with a median follow up of 7.4 yr (interquartile range 5.3-9.3) using validated food frequency questionnaires. Primary outcomes measured were total mortality and major cardiovascular events including fatal CVD, non- fatal myocardial infarction, stroke and heart failure. Secondary outcomes included all myocardial infarctions, CVD mortality, non-CVD mortality and stroke. The associations between consumption of total fat, and each type of fat, carbohydrate with CVD and total mortality were assessed. The study reported that with increase in the percentage of energy from carbohydrates, the incidence of mortality increased. The incidence of mortality was 4.1 [per 1000 person-years; 95% confidence interval (CI)] in the first quintile with median 46.4 per cent of energy from carbohydrates and 7.2 (per 1000 person-years; 95% CI) in the fifth quintile with median 77.2 per cent of energy from carbohydrates. Conversely, with increase in percentage of energy from fat (including saturated fat), the total mortality decreased.
Recently, Seidelmann et al have shown in an elegant study that very low carbohydrate (and hence, very high-fat) diets also increase the mortality. The authors reported that there was a U-shaped curve between carbohydrate intake and mortality. The optimal intake of carbohydrate appeared to be around 50-55 per cent of the total calories. As the carbohydrate percentage increases or decreases from this level, the mortality appeared to increase. They also showed that in the low carbohydrate group, those who ate animal protein and fat derived from meat products fared worse than those who took plant products.
| Conclusions|| |
There are evidence to suggest that excess carbohydrate is linked to both the susceptibility to T2D and also to poor control of diabetes and proneness to complications of diabetes, particularly in Asian populations. However, more than the quantity of carbohydrates, it is the quality of carbohydrates which is important. Thus, there are 'good carbs' such as whole grains, legumes, vegetables, whole fruits, nuts and seeds which canbe included in the diet. Conversely, the 'bad carbs' such as refined cereals such as WR and white bread, sugar-sweetened drinks or fruit juices, cookies and pastries should be restricted. Ultimately, it is all a matter of balanced diets and moderation in what one eats, is the key to a healthy diet. The take-home message for Indians (and Asians) would be to cut down the carbohydrate intake from the present 65-75 per cent to around 50-55 per cent add enough proteins, 20-25 per cent probably from vegetable sources such as legumes and pulses and the rest 20-30 per cent from healthy monounsaturated fats such as groundnut or mustard oil, nuts and seeds. This would make our diets healthier and sustainable in the long run.
Acknowledgment: This article is based on a debate on carbohydrate versus fats at the American Diabetes Association in Orlanda, USA on June 25, 2018 where the first author (VM) was asked to argue the case that excess carbohydrates were more detrimental than fats.
Financial support & sponsorship: None.
Conflicts of Interest: None.
| References|| |
International Diabetes Federation. IDF diabetes atlas
ed. Brussels, Belgium, International Diabetes Federation; 2017. Available from: http://www.diabetesatlas.org/resources/2017-atlas.html/
, accessed on September 8, 2018.
Anjana RM, Deepa M, Pradeepa R, Mahanta J, Narain K, Das HK, et al.
Prevalence of diabetes and prediabetes in 15 states of India: Results from the ICMR-INDIAB population-based cross-sectional study. Lancet Diabetes Endocrinol
Unnikrishnan R, Anjana RM, Mohan V. Diabetes in South Asians: Is the phenotype different? Diabetes
Anjana RM, Pradeepa R, Das AK, Deepa M, Bhansali A, Joshi SR, et al.
Physical activity and inactivity patterns in India - Results from the ICMR-INDIAB study (Phase-1) [ICMR-INDIAB-5]. Int J Behav Nutr Phys Act
Ludwig DS, Hu FB, Tappy L, Brand-Miller J. Dietary carbohydrates: Role of quality and quantity in chronic disease. BMJ
Radhika G, Sathya RM, Ganesan A, Saroja R, Vijayalakshmi P, Sudha V, et al.
Dietary profile of urban adult population in South India in the context of chronic disease epidemiology (CURES-68). Public Health Nutr
Ramachandran A, Snehalatha C, Mary S, Mukesh B, Bhaskar AD, Vijay V, et al.
The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1). Diabetologia
Joshi SR, Bhansali A, Bajaj S, Banzal SS, Dharmalingam M, Gupta S, et al.
Results from a dietary survey in an Indian T2DM population: A STARCH study. BMJ Open
Gross LS, Li L, Ford ES, Liu S. Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: An ecologic assessment. Am J Clin Nutr
Dekker MJ, Su Q, Baker C, Rutledge AC, Adeli K. Fructose: A highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome. Am J Physiol Endocrinol Metab
Ahuja MMS, editor. Epidemiological studies on diabetes mellitus in India. In: Epidemiology of diabetes in developing countries
. New Delhi: Inter Print; 1979. p. 29-38.
Gujral UP, Narayan KM, Kahn SE, Kanaya AM. The relative associations of β- cell function and insulin sensitivity with glycemic status and incident glycemic progression in migrant Asian Indians in the United States: The MASALA study. J Diabetes Complications
Ramachandran A, Snehalatha C, Kapur A, Vijay V, Mohan V, Das AK, et al.
High prevalence of diabetes and impaired glucose tolerance in India: National Urban Diabetes Survey. Diabetologia
Mohan V, Deepa M, Deepa R, Shanthirani CS, Farooq S, Ganesan A, et al.
Secular trends in the prevalence of diabetes and impaired glucose tolerance in urban South India - The Chennai Urban Rural Epidemiology Study (CURES-17). Diabetologia
Ramachandran A, Mary S, Yamuna A, Murugesan N, Snehalatha C. High prevalence of diabetes and cardiovascular risk factors associated withurbanization in India. Diabetes Care
Mohan V, Radhika G, Sathya RM, Tamil SR, Ganesan A, Sudha V, et al.
Dietary carbohydrates, glycaemic load, food groups and newly detected type 2 diabetes among urban Asian Indian population in Chennai, India (Chennai Urban Rural Epidemiology Study 59). Br J Nutr
Murakami K, Sasaki S, Takahashi Y, Okubo H, Hosoi Y, Horiguchi H, et al.
Dietary glycemic index and load in relation to metabolic risk factors in Japanese female farmers with traditional dietary habits. Am J Clin Nutr
AlEssa HB, Bhupathiraju SN, Malik VS, Wedick NM, Campos H, Rosner B, et al.
Carbohydrate quality and quantity and risk of type 2 diabetes in US women. Am J Clin Nutr
Lloyd-Jones DM, Hong Y, Labarthe D, Mozaffarian D, Appel LJ, Van Horn L, et al.
Defining and setting national goals for cardiovascular health promotion and disease reduction: The American Heart Association's strategic impact goalthrough 2020 and beyond. Circulation
Sakurai M, Nakamura K, Miura K, Takamura T, Yoshita K, Nagasawa SY, et al.
Dietary carbohydrate intake, presence of obesity and the incident risk of type 2 diabetes in Japanese men. J Diabetes Investig
Anjana RM, Shanthi Rani CS, Deepa M, Pradeepa R, Sudha V, Divya Nair H, et al.
Incidence of diabetes and prediabetes and predictors of progression among Asian Indians: 10-year follow-up of the Chennai Urban Rural Epidemiology Study (CURES). Diabetes Care
Hu EA, Pan A, Malik V, Sun Q. White rice consumption and risk of type 2 diabetes: Meta-analysis and systematic review. BMJ
Sun Q, Spiegelman D, van Dam RM, Holmes MD, Malik VS, Willett WC, et al.
White rice, brown rice, and risk of type 2 diabetes in US men and women. Arch Intern Med
Zhang G, Pan A, Zong G, Yu Z, Wu H, Chen X, et al.
Substituting white rice with brown rice for 16 does not substantially affect metabolic risk factors in middle-aged Chinese men and women with diabetes or a high risk for diabetes. J Nutr
Villegas R, Liu S, GaoYT, Yang G, Li H, Zheng W, et al.
Prospective study of dietary carbohydrates, glycemic index, glycemic load, and incidence of type 2 diabetes mellitus in middle-aged Chinese women. Arch Intern Med
Stern MP, Williams K, González-Villalpando C, Hunt KJ, Haffner SM. Does the metabolic syndrome improve identification of individuals at risk of type 2 diabetes and/or cardiovascular disease? Diabetes Care
Radhika G, Van Dam RM, Sudha V, GanesanA, Mohan V. Refined grain consumption and the metabolic syndrome in urban Asian Indians (Chennai Urban Rural Epidemiology Study 57). Metabolism
Park S, Ahn J, Kim NS, Lee BK. High carbohydrate diets are positively associated with the risk of metabolic syndrome irrespective to fatty acid composition in women: The KNHANES 2007-2014. Int J Food Sci Nutr
McKeown NM, Meigs JB, Liu S, Saltzman E, Wilson PW, Jacques PF, et al.
Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort. Diabetes Care
Liu S, Manson JE, Stampfer MJ, Holmes MD, Hu FB, Hankinson SE, et al.
Dietary glycemic load assessed by food-frequency questionnaire in relation to plasma high-density-lipoprotein cholesterol and fasting plasma triacylglycerols in postmenopausal women. Am J Clin Nutr
Liu S, Willett WC. Dietary glycemic load and atherothrombotic risk. Curr Atheroscler Rep
Lakshmipriya N, Gayathri R, PraseenaK, Vijayalakshmi P, Geetha G, Sudha V, et al.
Type of vegetable oils used in cooking and risk of metabolic syndrome among Asian Indians. Int J Food Sci Nutr
Barclay AW, Petocz P, McMillan-Price J, Flood VM, Prvan T, Mitchell P, et al.
Glycemic index, glycemic load, and chronic disease risk - A meta-analysis of observational studies. Am J Clin Nutr
Shadman Z, Khoshniat M, Poorsoltan N, Akhoundan M, Omidvar M, Larijani B, et al.
Association of high carbohydrate versus high fat diet with glycated hemoglobin in high calorie consuming type 2 diabetics. J Diabetes Metab Disord
vanWyk HJ, Davis RE, Davies JS. A critical review of low-carbohydrate diets in people with type 2 diabetes. Diabet Med
Mayer SB, Jeffreys AS, Olsen MK, McDuffie JR, Feinglos MN, Yancy WS Jr., et al.
Two diets with different haemoglobinA1c and antiglycaemic medication effects despite similar weight loss in type 2 diabetes. Diabetes Obes Metab
Snorgaard O, Poulsen GM, Andersen HK, Astrup A. Systematic review and meta- analysis of dietary carbohydrate restriction in patients with type 2 diabetes. BMJ Open Diabetes Res Care
Brehm BJ, Lattin BL, Summer SS, Boback JA, Gilchrist GM, Jandacek RJ, et al.
One-year comparison of a high-monounsaturated fat diet with a high-carbohydrate diet in type 2 diabetes. Diabetes Care
Diabetes Prevention Program (DPP) Research Group. The Diabetes Prevention Program (DPP): description of lifestyle intervention. Diabetes Care
Stentz FB, Brewer A, Wan J, Garber C, Daniels B, Sands C, et al.
Remission of pre-diabetes to normal glucose tolerance in obese adults with high protein versus high carbohydrate diet: Randomized control trial. BMJ Open Diabetes Res Care
Weber MB, Ranjani H, Meyers GC, Mohan V, Narayan KM. A model of translational research for diabetes prevention in low and middle-income countries: The Diabetes Community Lifestyle Improvement Program (D-CLIP) trial. Prim Care Diabetes
Juraschek SP, Chang AR, Appel LJ, Anderson CA, Crews DC, Thomas L, et al.
Effect of glycemic index and carbohydrate intake on kidney function in healthy adults. BMC Nephrol
McMillan-Price J, Brand-Miller J. Low-glycaemic index diets and body weight regulation. Int J Obes
Jenkins DJ, Kendall CW, Augustin LS, Mitchell S, Sahye-Pudaruth S, Blanco Mejia S, et al.
Effect of legumes as part of a low glycemic index diet on glycemic control and cardiovascular risk factors in type 2 diabetes mellitus: A randomized controlled trial. Arch Intern Med
Dehghan M, Mente A, Zhang X, Swaminathan S, Li W, Mohan V, et al.
Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): A prospective cohort study. Lancet
Seidelmann SB, Claggett B, Cheng S, Henglin M, Shah A, Steffen LM, et al.
Dietary carbohydrate intake and mortality: A prospective cohort study and meta- analysis. Lancet Public Health