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ORIGINAL ARTICLE
Year : 2018  |  Volume : 148  |  Issue : 3  |  Page : 317-322

Association of reduced count of interleukin-13-producing cells in breast milk with atopic dermatitis in infancy


1 Department of Immunology; Cardiovascular Research Center, Institute of Basic and Clinical Physiology, Kerman, Iran
2 Department of Microbiology & Immunology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
3 Department of Allergy & Clinical Immunology, Faculty of Medicine, Kerman, Iran
4 Modeling in Health Research Center, Kerman University of Medical Sciences, Kerman, Iran
5 Department of Immunology; Physiology Research Center, Institute of Basic and Clinical Physiology, Kerman, Iran

Correspondence Address:
Dr Mohammad Mahdi Mohammadi
Department of Immunology, Physiology Research Center, Institute of Basic and Clinical Physiology, Kerman University of Medical Sciences, P.O. Box 444, Kerman 76169-14115
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_1682_16

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Background & objectives: Atopic dermatitis (AD) is one of the most common pathologic conditions of skin in children. The effect of breastfeeding on the risk of AD remains controversial. The aim of this study was to determine the counts of cytokine-producing cells in the mothers' breast milk of infants with and without AD to assess association, if any. Methods: Breast milk samples (10 ml) were obtained from mothers of 25 infants with AD and of 26 healthy infants as a control group. The number of cytokine-producing cells including interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α), interleukin-13 (IL-13) and IL-4 in the milk samples was determined using an enzyme-linked immunospot assay technique. Results: The mean of IL-13-producing cells in milk was significantly lower in mothers of AD-affected infants in comparison with mothers of normal infants (324.91±255.45 vs. 538.93±465.39, P<0.05). There were no significant differences between mothers of infants with and without AD regarding milk count of IFN-γ-, TNF-α- and IL-4-producing cells. Interpretation & conclusions: Our results showed lower number of IL-13-producing cells in milk of mothers of infants with AD. Therefore, lower count of IL-13-producing cells in mothers' milk may confer a susceptibility to AD. Further studies with a large number of samples need to be done to confirm our findings.


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