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REVIEW ARTICLE
Year : 2018  |  Volume : 147  |  Issue : 4  |  Page : 341-351

Oxidative stress as a possible pathogenic cofactor of post-menopausal osteoporosis: Existing evidence in support of the axis oestrogen deficiency-redox imbalance-bone loss


1 Menopause & Osteoporosis Centre; Section of Obstetrics & Gynecology, Department of Morphology, Surgery & Experimental Medicine, University of Ferrara, Ferrara, Italy
2 Menopause & Osteoporosis Centre, Department of Morphology, Surgery & Experimental Medicine, University of Ferrara, Ferrara, Italy
3 Section of Medical Biochemistry, Molecular Biology & Genetics, Department of Biomedical & Specialist Surgical Sciences, University of Ferrara, Ferrara, Italy

Correspondence Address:
Dr Carlo Cervellati
Department of Biomedical & Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology & Genetics, University of Ferrara, Via Borsari 46, 44121, Ferrara
Italy
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_524_18

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Post-menopausal osteoporosis (PO) is one of the major health issues associated with menopause-related oestrogen withdrawal. Despite the intense research and the relevant progress achieved in the last two decades, the pathogenic mechanism underlying PO is still poorly understood. As a consequence of this gap in the knowledge, such disorder and the related complications are still difficult to be effectively prevented. A wealth of experimental and epidemiological/clinical evidence suggests that the endocrine change associated to menopausal transition might lead to a derangement of redox homeostasis, that is, the prelude to the health-threaten condition of oxidative stress (OxS). In turn, this (bio)chemical stress has been widely hypothesized to contribute, most likely in synergy with inflammation, to the development of menopause-related diseases, including PO. The main aim of this review is to discuss the current literature evidence on the association between post-menopausal oestrogen withdrawal, OxS and PO. It is also aimed to provide a critical overview of the most significant epidemiological studies on the effects of dietary antioxidants on bone health and to devise a strategy to overcome the limitations emerged and controversial results.


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