Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
  Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login  
  Home Print this page Email this page Small font sizeDefault font sizeIncrease font size Users Online: 721       
ORIGINAL ARTICLE
Year : 2018  |  Volume : 147  |  Issue : 1  |  Page : 73-80

Cytopenia in adult brucellosis patients


1 Department of Infectious Diseases & Clinical Microbiology, Gazi Yasargil Training & Research Hospital, Diyarbakir, Turkey
2 Department of Infectious Diseases & Clinical Microbiology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
3 Department of Infectious Diseases & Clinical Microbiology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
4 Department of Internal Medicine, Division of Hematology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey
5 Department of Infectious Diseases & Clinical Microbiology, Bismil State Hospital, Diyarbakir, Turkey

Correspondence Address:
Dr Safak Kaya
Department of Infectious Diseases & Clinical Microbiology, Gazi Yasargil Training & Research Hospital, Diyarbakir 21100
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_542_15

Rights and Permissions

Background & objectives: Brucellosis can lead to haematological abnormalities including cytopenia confusing with haematological malignancies. The aim of this study was to compare the main characteristics of brucellosis patients without cytopenia (Group 1) and with cytopenia (Group 2). Methods: This five-year period study which was performed in two referral hospitals in Turkey, included all adult brucellosis patients. Abnormally, low counts of leucocyte or haemoglobin or platelets in a patient were considered as cytopenia. The demographics, clinical, laboratory, treatment and outcome data were analyzed. Results: A total of 484 brucellosis patients were enrolled. Among the cases, 162 (33.5%) of them had cytopenia. One hundred and four (21.5%) had anaemia, 88 (18.8%) had thrombocytopenia, 71 (14.6%) had leucopenia and 28 (5.8%) had pancytopenia. The mean age of group 2 was 35.01±16.05 yr and it was 33.31±14.39 yr in group 1. While there was no difference between the groups in terms of duration of treatment, the median length of hospital stay (LOS) was significantly longer in group 2 (9 vs 10 days; P<0.001). The most frequently applied combination therapy consisted of doxycycline plus rifampicin and doxycycline plus streptomycin regimens. No significant difference was observed in terms of duration of treatment, LOS and restoration time of cytopenia between the patients who received either of these combinations. Interpretation & conclusions: Our findings suggested that the patients with cytopenia should be investigated for brucellosis, especially if living in, or with a history of travel to, endemic areas, in view of the increase in world travel.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed711    
    Printed5    
    Emailed0    
    PDF Downloaded229    
    Comments [Add]    
    Cited by others 2    

Recommend this journal