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ORIGINAL ARTICLE
Year : 2016  |  Volume : 144  |  Issue : 6  |  Page : 823-830

Number of decidual natural killer cells & macrophages in pre-eclampsia


1 Department of Gynecology & Obstetrics; Department of Clinic of Gynecology & Obstetrics, Clinical Center Nis, Nis, Serbia
2 Department of Pathology, Faculty of Medicine, University of Nis; Department of Pathology & Pathological Anatomy Center, Clinical Center Nis, Nis, Serbia
3 Department of Clinic of Gynecology & Obstetrics, Clinical Center Nis, Nis, Serbia
4 Department of Pathology, Faculty of Medicine, University of Nis, Nis, Serbia

Correspondence Address:
Jelena Milosevic-Stevanovic
Clinic of Gynecology & Obstetrics, Clinical Center Nis, Blvd. Dr Zorana Djindjica 48, Nis 18000
Serbia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmr.IJMR_776_15

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Background & objectives: The process of human placentation is complex and still not well understood. This study was aimed to examine the relationship between clinical features of pre-eclampsia and degree of trophoblastic invasion after its immunohistochemical visualization in the context of possible alterations in the number of natural killer (NK) cells and macrophages in the decidua. Methods: This prospective study included a study group comprising 30 pregnant women with pre-eclampsia delivered by caesarean section and a control group comprising 20 healthy pregnant women also delivered by caesarean section. Samples of placental bed obtained during caesarean section were analyzed after immunohistochemical labelling CD56 + NK cells, CD68 + macrophages and cytokeratin 7 trophoblastic cells. Results: In pre-eclampsia, there was a significantly lower number of CD56 + NK cells in the decidua (P<0.001) and a higher number of CD68 + macrophages (P<0.001) compared to control group. In the subgroup of pre-eclampsia with intrauterine growth retardation (IUGR), a significantly greater number of NK cells (P<0.05) was recorded, as well as an increased number of macrophages, but not significantly compared to pre-eclampsia without IUGR. There was no significant difference in the distribution of these cells in the decidua in relation to the severity of pre-eclampsia. CD56 + NK cells were significantly less (P<0.05) and macrophages were more (P<0.05) in the group with poor trophoblastic invasion. Interpretation & conclusions: Alterations in the number of immune cells in relation to the degree of trophoblastic invasion indicated their role in aetiopathogenesis of pre-eclampsia, while the direct association between their number and severity of pre-eclampsia was not confirmed.


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