Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
  Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login  
  Home Print this page Email this page Small font sizeDefault font sizeIncrease font size Users Online: 470       
REVIEW ARTICLE
Year : 2016  |  Volume : 144  |  Issue : 4  |  Page : 515-524

Apoptosis, autophagy & endoplasmic reticulum stress in diabetes mellitus


1 Department of Internal Medicine, Erzincan University, Erzincan, Turkey
2 Division of Nephrology, Kırsehir Training and Research Hospital, Kırsehir, Turkey
3 Department of Internal Medicine, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey
4 Department of Reanimation & Anesthesiology, Erzincan University, Erzincan, Turkey

Correspondence Address:
Kultigin Turkmen
Department of Internal Medicine, Division of Nephrology, Necmettin Erbakan University, Meram School of Medicine, 42090, Konya
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-5916.200887

Rights and Permissions

The prevalence of diabetes mellitus (DM) is increasing secondary to increased consumption of food and decreased physical activity worldwide. Hyperglycaemia, insulin resistance and hypertrophy of pancreatic beta cells occur in the early phase of diabetes. However, with the progression of diabetes, dysfunction and loss of beta cells occur in both types 1 and 2 DM. Programmed cell death also named apoptosis is found to be associated with diabetes, and apoptosis of beta cells might be the main mechanism of relative insulin deficiency in DM. Autophagic cell death and apoptosis are not entirely distinct programmed cell death mechanisms and share many of the regulator proteins. These processes can occur in both physiologic and pathologic conditions including DM. Besides these two important pathways, endoplasmic reticulum (ER) also acts as a cell sensor to monitor and maintain cellular homeostasis. ER stress has been found to be associated with autophagy and apoptosis. This review was aimed to describe the interactions between apoptosis, autophagy and ER stress pathways in DM.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed606    
    Printed4    
    Emailed0    
    PDF Downloaded277    
    Comments [Add]    

Recommend this journal