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CORRESPONDENCE
Year : 2016  |  Volume : 143  |  Issue : 6  |  Page : 833

Authors' response


1 Army Hospital (Research & Referral), New Delhi, India
2 Military Hospital, Cardio Thoracic Centre, Pune, India
3 Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
4 Christian Medical College, Vellore, India
5 Postgraduate Institute of Medical Education & Research, Chandhigarh, India
6 All India Institute of Medical Sciences, New Delhi, India
7 Department of Biotechnology, Government of India, New Delhi, India
8 Institute of Nuclear Medicine & Allied Sciences, Delhi, India

Date of Web Publication12-Oct-2016

Correspondence Address:
V Nair
Army Hospital (Research & Referral), New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-5916.192081

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How to cite this article:
Nair V, Madan H, Sofat S, Ganguli P, Jacob M J, Datta R, Bharadwaj P, Sarkar R S, Pandit A J, Nityanand S, Goel P K, Garg N, Gambhir S, George P V, Chandy S, Mathews V, George O K, Talwar K K, Bahl A, Marwah N, Bhatacharya A, Bhargava B, Airan B, Mohanty S, Patel C D, Sharma A, Bhatnagar S, Mondal A, Jose J, Srivastava A, for MI3 Trial. Authors' response. Indian J Med Res 2016;143:833

How to cite this URL:
Nair V, Madan H, Sofat S, Ganguli P, Jacob M J, Datta R, Bharadwaj P, Sarkar R S, Pandit A J, Nityanand S, Goel P K, Garg N, Gambhir S, George P V, Chandy S, Mathews V, George O K, Talwar K K, Bahl A, Marwah N, Bhatacharya A, Bhargava B, Airan B, Mohanty S, Patel C D, Sharma A, Bhatnagar S, Mondal A, Jose J, Srivastava A, for MI3 Trial. Authors' response. Indian J Med Res [serial online] 2016 [cited 2019 Oct 21];143:833. Available from: http://www.ijmr.org.in/text.asp?2016/143/6/833/192081

All Authors for MI3 Trial


We thank Deepa Bhartiya for her comments on our article published resently [1] .

We have the following comments:

  1. This study was firstly not undertaken based on the results of the pilot ABCD study reported from AIIMS, New Delhi, as suggested by Deepa Bhartiya. Our study was based on an extensive Cochrane review [2] of all relevant published literature on this subject at that point of time.
  2. This phase III prospective, open labelled, randomized multicenteric trial was conducted from 2007 to 2010 and only relevant issues were highlighted in the discussion pertaining to the trial period. Hence, the contention that no articles published from 2013-2015 having been cited should not be surprising. At no stage, even remotely, have we suggested that no progress has been made in this field as mentioned in the letter [3] . On the contrary, we agree that significant progress has been made in the field of stem cells and mesenchymal stem cells (MSC) worldwide.
  3. Regarding the point raised about MSCs ability to differentiate into cardiac cells we would like to highlight that MSCs have already been differentiated in vitro using different growth factors and chemicals into cardiomyocytes and neurons [4],[5] .
  4. The author's remaining comments mostly are not relevant to our article as she has discussed extensively on VSELs. However, as is known it has its own controversies in the scientific literature.


 
   References Top

1.
Nair V, Madan H, Sofat S, Ganguli P, Jacob MJ, Datta R, et al for M13 Trial. Efficacy of stem cell in improvement of left ventricular function in acute myocardial infarction-M13 Trial. Indian J Med Res 2015; 142 : 165-74.  Back to cited text no. 1
    
2.
Clifford DM, Fisher SA, Brunskill SJ, Doree C, Mathur A, Watt S, et al. Stem cell treatment for acute myocardial infarction. Cochrane Database Syst Rev 2012; 2 : CD006536.  Back to cited text no. 2
    
3.
Bhartiya D. National multicentric M13 Stem Cell Trial reports negative outcome - Need to look at VSELs as an alternative to bone marrow MNCs for cardiac regeneration. Indian J Med Res 2016; 143 : 830-2.  Back to cited text no. 3
    
4.
Xu W, Zhang X, Qian H, Zhu W, Sun X, Hu J, et al. Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro. Exp Biol Med (Maywood) 2004; 229 : 623-31.  Back to cited text no. 4
[PUBMED]    
5.
Mohanty S, Bose S, Jain KG, Bhargava B, Airan B. TGFβ1 contributes to cardiomyogenic - like differentiation of human bone marrow mesenchymal stem cells. Int J Cardiol 2013; 163 : 93-9.  Back to cited text no. 5
[PUBMED]    




 

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