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REVIEW ARTICLE
Year : 2016  |  Volume : 143  |  Issue : 6  |  Page : 696-711

Strategies & recent development of transmission-blocking vaccines against Plasmodium falciparum


1 National Institute for Research in Tribal Health (ICMR), Jabalpur, School of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya (State Technological University of Madhya Pradesh), Bhopal, India
2 National Institute for Research in Tribal Health (ICMR), Jabalpur, India
3 School of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya (State Technological University of Madhya Pradesh), Bhopal, India

Correspondence Address:
Neeru Singh
National Institute for Research in Tribal Health (NIRTH), [Formerly Regional Medical Research Centre for Tribals (RMRCT)], NIRTH (ICMR) campus, Nagpur Road, Garha, Jabalpur 482 003, Madhya Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-5916.191927

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Transmission blocking malaria vaccines are aimed to block the development and maturity of sexual stages of parasite within mosquitoes. The vaccine candidate antigens (Pfs25, Pfs48/45, Pfs230) that have shown transmission blocking immunity in model systems are in different stages of development. These antigens are immunogenic with limited genetic diversity. Pfs25 is a leading candidate and currently in phase I clinical trial. Efforts are now focused on the cost-effective production of potent antigens using safe adjuvants and optimization of vaccine delivery system that are capable of inducing strong immune responses. This review addresses the potential usefulness, development strategies, challenges, clinical trials and current status of Plasmodium falciparum sexual stage malaria vaccine candidate antigens for the development of transmission-blocking vaccines.


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