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ORIGINAL ARTICLE
Year : 2016  |  Volume : 143  |  Issue : 2  |  Page : 175-183

Hair & skin derived progenitor cells: In search of a candidate cell for regenerative medicine


1 Stem Cell Facility, All India Institute of Medical Sciences, New Delhi; Amity Institute of Biotechnology, Amity University Gurgaon, Haryana, India
2 Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
3 Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India; Department of Biomedical Sciences, Texas Tech University Health Sciences Center, EI Paso, Texas, United States, India
4 Department of Dermatology, All India Institute of Medical Sciences, New Delhi, India
5 Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India
6 Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India
7 Department of Cardio-Thoracic Vascular Surgery, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Sujata Mohanty
Stem Cell Facility, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-5916.180205

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Background & objectives: Skin is an established tissue source for cell based therapy. The hair follicle has been introduced later as a tissue source for cell based therapy. The ease of tissue harvest and multipotent nature of the resident stem cells in skin and hair follicle has promoted basic and clinical research in this area. This study was conducted to evaluate skin stem cells (SSCs) and hair follicle stem cells (HFSCs) as candidate cells appropriate for neuronal and melanocyte lineage differentiation. Methods: In this study, SSCs and hair follicle stem cells (HFSCs) were expanded in vitro by explant culture method and were compared in terms of proliferative potential and stemness; differentiation potential into melanocytes and neuronal lineage. Results: SSCs were found to be more proliferative in comparison to HFSCs, however, telomerase activity was more in HFSCs in comparison to SSCs. Capacity to differentiate into two lineages of ectoderm origin (neuronal and melanocyte) was found to be different. HFSCs cells showed more propensities towards melanocyte lineage, whereas SSCs were more inclined towards neuronal lineage. Interpretation & conclusions: The study showed that SSCs had differential advantage over the HFSCs for neuronal cell differentiation, whereas, the HFSCs were better source for melanocytic differentiation.


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