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CORRESPONDENCE
Year : 2015  |  Volume : 142  |  Issue : 5  |  Page : 618

Age, gender & co-morbidities as risk factors for drug-induced diseases


1 Department of Infectious Diseases & Clinical Microbiology, Dr. Munif Islamoglu Kastamonu State Hospital, Kastamonu, Turkey
2 Department of Endocrinology & Metabolism, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey

Date of Web Publication9-Dec-2015

Correspondence Address:
Hasan Tahsin Gozdas
Department of Infectious Diseases & Clinical Microbiology, Dr. Munif Islamoglu Kastamonu State Hospital, Kastamonu
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-5916.171297

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How to cite this article:
Gozdas HT, Arpaci D. Age, gender & co-morbidities as risk factors for drug-induced diseases . Indian J Med Res 2015;142:618

How to cite this URL:
Gozdas HT, Arpaci D. Age, gender & co-morbidities as risk factors for drug-induced diseases . Indian J Med Res [serial online] 2015 [cited 2020 Feb 26];142:618. Available from: http://www.ijmr.org.in/text.asp?2015/142/5/618/171297

Sir,

The study by Tandon and colleagues [1] on drug-induced diseases (DIDs) is very interesting. However, we have some comments regarding this study. An important portion of the study population was geriatric patients (54%). Also, the number of females was significantly more than males (1.7 vs 1). As stated by Zopf et al[2] , advanced age and female gender were important risk factors for DIDs. So, these two factors might have significantly affected the results of this study.

As seen in Table I0 , there was a significant difference between the number of patients with single disease and co-morbid conditions ( P<0.001). It would be important to know how many patient in this study had diabetes mellitus, chronic renal insufficiency, hepatic insufficiency or AIDS. Because, such co-morbidities cause secondary immune deficiencies and patients having these co-morbidities are more susceptible to adverse effects of immunosuppressive medications such as methotrexate, cyclophosphamide and corticosteroids [3] .



 
   References Top

1.
Tandon VR, Khajuria V, Mahajan V, Sharma A, Gillani Z, Mahajan A. Drug-induced diseases (DIDs): An experience of a tertiary care teaching hospital from India. Indian J Med Res 2015; 142 : 33-9.  Back to cited text no. 1
    
2.
Zopf Y, Rabe C, Neubert A, Hahn EG, Dormann H. Risk factors associated with adverse drug reactions following hospital admission: a prospective analysis of 907 patients in two German university hospitals. Drug Saf 2008; 31 : 789-98.  Back to cited text no. 2
    
3.
de Marie S. Diseases and drug-related interventions affecting host defence. Eur J Clin Microbiol Infect Dis 1993; 12 (Suppl 1): S36-41.  Back to cited text no. 3
    




 

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