|Year : 2015 | Volume
| Issue : 5 | Page : 618
Age, gender & co-morbidities as risk factors for drug-induced diseases
Hasan Tahsin Gozdas1, Dilek Arpaci2
1 Department of Infectious Diseases & Clinical Microbiology, Dr. Munif Islamoglu Kastamonu State Hospital, Kastamonu, Turkey
2 Department of Endocrinology & Metabolism, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey
|Date of Web Publication||9-Dec-2015|
Hasan Tahsin Gozdas
Department of Infectious Diseases & Clinical Microbiology, Dr. Munif Islamoglu Kastamonu State Hospital, Kastamonu
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Gozdas HT, Arpaci D. Age, gender & co-morbidities as risk factors for drug-induced diseases
. Indian J Med Res 2015;142:618
The study by Tandon and colleagues  on drug-induced diseases (DIDs) is very interesting. However, we have some comments regarding this study. An important portion of the study population was geriatric patients (54%). Also, the number of females was significantly more than males (1.7 vs 1). As stated by Zopf et al , advanced age and female gender were important risk factors for DIDs. So, these two factors might have significantly affected the results of this study.
As seen in Table I0 , there was a significant difference between the number of patients with single disease and co-morbid conditions ( P<0.001). It would be important to know how many patient in this study had diabetes mellitus, chronic renal insufficiency, hepatic insufficiency or AIDS. Because, such co-morbidities cause secondary immune deficiencies and patients having these co-morbidities are more susceptible to adverse effects of immunosuppressive medications such as methotrexate, cyclophosphamide and corticosteroids  .
| References|| |
Tandon VR, Khajuria V, Mahajan V, Sharma A, Gillani Z, Mahajan A. Drug-induced diseases (DIDs): An experience of a tertiary care teaching hospital from India. Indian J Med Res
Zopf Y, Rabe C, Neubert A, Hahn EG, Dormann H. Risk factors associated with adverse drug reactions following hospital admission: a prospective analysis of 907 patients in two German university hospitals. Drug Saf
de Marie S. Diseases and drug-related interventions affecting host defence. Eur J Clin Microbiol Infect Dis
(Suppl 1): S36-41.