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REVIEW ARTICLE
Year : 2015  |  Volume : 141  |  Issue : 2  |  Page : 172-174

Current advances related to Clostridium difficile infection


1 Institute for Digestive Research, Digestive Disease Center, Department of Internal Medicine, Soonchunhyang University Gumi Hospital, Soonchunhyang University College of Medicine, Gumi, South Korea
2 Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, South Korea

Correspondence Address:
Dr. Byung Ik Jang
Department of Internal Medicine, Yeungnam University College of Medicine, Daegu
South Korea
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-5916.155545

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Clostridium difficile infection (CDI) can trigger various responses, ranging from asymptomatic carriage to fulminant colitis. Hard-to-cure CDI, such as severe CDI, multiple recurrences of CDI, refractory CDI, and hypervirulent strains of C. difficile, require new treatments, although antibiotics such as metronidazole and vancomycin are the treatment of choice for initial and first relapsing CDI. Active immunization with C. difficile toxins and faecal microbiota transplantation deserve special attention. Here we describe these strategies for difficult-to-treat CDI.


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