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BOOK REVIEW
Year : 2015  |  Volume : 141  |  Issue : 1  |  Page : 136

Proton pump inhibitors: A balanced view


Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India

Date of Web Publication2-Apr-2015

Correspondence Address:
U C Ghoshal
Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014
India
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Source of Support: None, Conflict of Interest: None


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How to cite this article:
Ghoshal U C. Proton pump inhibitors: A balanced view. Indian J Med Res 2015;141:136

How to cite this URL:
Ghoshal U C. Proton pump inhibitors: A balanced view. Indian J Med Res [serial online] 2015 [cited 2019 Aug 25];141:136. Available from: http://www.ijmr.org.in/text.asp?2015/141/1/136/154527

Proton pump inhibitors: A balanced view, T. Chiba, P. Malfertheiner, H. Satoh, editors (Karger, Basel, Switzerland) 119 pages. 2013. Price: US$ 209.00 / CHF 178.00 / EUR 148.0

ISBN: 978-3-318-02415-9

Proton pump inhibitors (PPIs), which block the final common pathway of gastric acid secretion, have revolutionized the management of several gastro-duodenal diseases such as gastroesophageal reflux disease, peptic ulcer (including bleeding ulcer), functional dyspepsia, and non-steroidal anti-inflammatory drug (NSAID) associated gastrointestinal injury. The PPIs are also important components of regimens to eradicate gastric Helicobacter pylori infection. It is noteworthy that with the availability of PPIs, surgical treatment of peptic ulcer disease, has now become almost obsolete.

There are several types of PPIs such as omeprazole, pantoprazole, lansoprazole, rabeprazole, esomeprazole, ilaprazole, etc. These molecules have some differences in dose, metabolism, drug interaction, acid suppressive capacity and duration of action. Currently, PPIs are widely prescribed formulations in medical practice in general and gastroenterology in particular. However, it is important that physicians prescribing PPIs be familiar with the pharmacokinetics, absorption, drug interaction and side effects of these molecules. Most believe that PPIs, even on long-term use, are free from any side effects, but over time researchers have realized that such a belief is far from being absolutely correct. Quite a few side effects of PPIs have been recognized recently, particularly on long-term use. Some of these include small intestinal bacterial overgrowth, bone disease including fracture, hypomagnesemia, fundic polyp, etc. Though it is important to note that most of these side effects are quite minor and clinically not very significant, but some of these may be significant in an occasional patient. Therefore, a physician's knowledge about these side effects is important for early recognition.

The book is divided into 10 chapters. Each of these chapters is written by experts in the field and it is heartening to note that some of these experts have been involved in original research on the development of PPIs. There are several colour and line diagrams that have made this complex subject very simple. Inclusion of a large number of tables contributes towards improved readability of this book.

The book has been correctly named as "Proton Pump Inhibitors: A Balanced View" as the authors have been able to present extensive amount of complex literature on the subject in a very balanced and simple manner. This book will be an asset to practicing physicians and gastroenterologists who often prescribe PPIs to treat their patients, as also for postgraduate students in Medicine as an extensive amount of literature has been reviewed in an easy-to-understand way. The history of the development of PPIs has also been reviewed with reasonable details, which may be of added value for postgraduate students and researchers in the field.




 

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