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CLINICAL IMAGES
Year : 2014  |  Volume : 140  |  Issue : 3  |  Page : 443-444

Myoepithelial cell carcinoma of the oral cavity


1 Department of Oral Pathology & Microbiology M. A. Rangoonwala College of Dental Sciences & Research Centre, India
2 Department of Dentistry Yashwantrao Chavan Memorial Hospital , Pimpri, Pune 411 018, India

Date of Web Publication1-Nov-2014

Correspondence Address:
Amisha A Shah
Department of Oral Pathology & Microbiology M. A. Rangoonwala College of Dental Sciences & Research Centre
India
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Source of Support: None, Conflict of Interest: None


PMID: 25366216

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How to cite this article:
Shah AA, Ingle Y. Myoepithelial cell carcinoma of the oral cavity . Indian J Med Res 2014;140:443-4

How to cite this URL:
Shah AA, Ingle Y. Myoepithelial cell carcinoma of the oral cavity . Indian J Med Res [serial online] 2014 [cited 2020 Feb 22];140:443-4. Available from: http://www.ijmr.org.in/text.asp?2014/140/3/443/143795

A 42 year old male, visited the Yashwantrao Chavan Memorial Hospital, Pune, Maharashtra, India, in February 2009, with pain and recurrent swelling in the lower jaw region since last one month [Figure 1]. A swelling with blue black discoloration and with irregular surface was present on the alveolar ridge [Figure 2]a. Post-incisional biopsy the lesion enlarged enormously reaching up to 7 cm x 5 cm in size [Figure 2]b. The patient had multiple neurofibromas all over his body [Figure 1]. o0 rthopentomogram showed a well defined lytic lesion along with a floating tooth [Figure 3].
Figure 1. Extra-oral right mandibular swelling (circle) with multiple lesions of neurofibromas (arrows).

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Figure 2: a. Small intra-oral lesion growing on the right mandibular alveolus. Fig. 2b. Rapidly growing lesion after inicisional biopsy almost filling up the entire oral cavity, measuring 7×5 cm in size.

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{Figure 3}

Histopathology confirmed the diagnosis of myoepithelial carcinoma (MC) metastasizing to the lymphnodes [Figure 4]a and [Figure 4]b. Hemimandibulectomy with radical neck dissection was performed in April 2009. Post-opetative radiotherapy was also given.The lesion recurred after eight months and thereafter the patient died in January 2010.
Figure 4: a & b. Myoepithelial carcinoma predominantly composed of plasmacytoid cells ( Fig. 4a -black arrows) in sheets, were separated by abundant pink, acellular and eosinophilic basement membrane like material ( Fig. 4b -black arrows). cellular atypia and high mitotic activity can be noted (H & E 40x).

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MC is a relatively rare salivary gland tumour with clinicopathologic diversity and a variety of stages of myoepithelial differentiation. Histologic aggressiveness, marked cellular pleomorphism, and high cell proliferative activity are usually related with poor clinical outcome.




    Figures

  [Figure 1], [Figure 2], [Figure 2], [Figure 4]



 

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