Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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ORIGINAL ARTICLE
Year : 2014  |  Volume : 139  |  Issue : 4  |  Page : 555-560

Bioevaluation of 125 I Ocu-Prosta seeds for application in prostate cancer brachytherapy


1 Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India
2 Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
3 Division of Animal Oncology, Advanced Centre for Treatment, Research & Education in Cancer, Navi Mumbai, India
4 Department of Radiation Oncology, Advanced Centre for Treatment, Research & Education in Cancer, Navi Mumbai, India

Correspondence Address:
Grace Samuel
Head, Radiopharmaceuticals Evaluation Section, Radiopharmaceuticals Division Bhabha Atomic Research Centre, Mumbai 400 085
India
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Source of Support: None, Conflict of Interest: None


PMID: 24927341

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Background & objectives: In recent years, brachytherapy involving permanent radioactive seed implantation has emerged as an effective modality for the management of cancer of prostate. 125 I-Ocu-Prosta seeds were indigenously developed and studies were carried out to assess the safety of the indigenously developed 125 I-Ocu-Prosta seeds for treatment of prostate cancer. Methods: Animal experiments were performed to assess the likelihood of in vivo release of 125 I from radioactive seeds and migration of seeds implanted in the prostate gland of the rabbit. In vivo release of 125 I activity was monitored by serial blood sampling from the auricular vein and subsequent measurement of 125 I activity. Serial computed tomography (CT) scans were done at regular intervals till 6 months post implant to assess the physical migration of the seeds. Results: The laser welded seeds maintained their hermeticity and prevented the in vivo release of 125 I activity into the blood as no radioactivity was detected during follow up blood measurements. Our study showed that the miniature 125 I seeds were clearly resolved in CT images. Seeds remained within the prostate gland during the entire study period. Moreover, the seed displacement was minimal even within the prostate gland. Interpretation & conclusions: Our findings have demonstrated that indigenously developed 125 I-Ocu-Prosta seeds may be suitable for application in treatment of prostate cancer.


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