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BOOK REVIEW
Year : 2014  |  Volume : 139  |  Issue : 3  |  Page : 477-478

Pituitary Today II: New molecular, physiological and clinical aspects


KPC Medical College & Consultant Endocrinologist RTIICS, 36 Block H New Alipore Kolkata 700 053, India

Date of Web Publication9-May-2014

Correspondence Address:
Debmalya Sanyal
KPC Medical College & Consultant Endocrinologist RTIICS, 36 Block H New Alipore Kolkata 700 053
India
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Source of Support: None, Conflict of Interest: None


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How to cite this article:
Sanyal D. Pituitary Today II: New molecular, physiological and clinical aspects. Indian J Med Res 2014;139:477-8

How to cite this URL:
Sanyal D. Pituitary Today II: New molecular, physiological and clinical aspects. Indian J Med Res [serial online] 2014 [cited 2020 Mar 29];139:477-8. Available from: http://www.ijmr.org.in/text.asp?2014/139/3/477/132219

Vol.38 (Frontiers of Hormone Research, Grossman AB, editor) E. Arzt, M. Bronstein, M. Guitelman, editors (Karger, Basel, Switzerland). 218 pages. Price: US$ 212.00, CHF 180.00

ISBN 978-3-8055-9444-8

Function and disease of the pituitary, albeit the "master gland" of the endocrine system, have long been at the center of research in endocrinology. Major advances have been made in unravelling the complex molecular biology and genetics of pituitary hormone production and action, opening up new management avenues. There is now a better understanding of the physiology and pathogenesis of pituitary diseases, tumours and clinical syndromes resulting in perturbation of pituitary function. There have also been major advances in the clinical management of pituitary disorders with new drugs and improved drug delivery systems of established drugs, facilitating better medical management of acromegaly and prolactinoma. These developments have improved the worldwide consensus of the definition of 'cure of pituitary disease', especially the hormone hypersecretion states. Based on these deliberations, a scientific meeting was held in Angro dos Reis, Brazil, in the backdrop of International Society of Endocrinology meeting in 2008. This book presents the latest in pituitary research, starting from genetics and pathogenesis to diagnostics and therapy of pituitary disease and tumours.

This book has been divided into 25 chapters with topics covering pituitary cell development and organization, genetics, pathogenesis and diagnostics of pituitary tumours, prolactinomas, acromegaly, Cushing's disease, hypothalamic-pituitary adrenal axis and adult growth hormone deficiency. The initial part deals with the molecular and genetic basis of pituitary tumorigenesis delving into the role of RSUME (a pituitary cell line gene) and cytokines of the IL-6 or gp 130 family. Stem cells, differentiation, cell cycle control, senescence and apoptosis regulation of pituitary gland and pituitary tumours are dissected in detail, which may be a little difficult to grasp for the practitioners but is a veritable goldmine for researchers on the subject. The chapter titled "Pituitary Carcinomas" exhaustively deals with a rarely discussed important topic, starting from molecular pathogenesis and markers of aggressiveness to diagnosis and detailed discussion on treatment. This book throws new light on gender differences, clinical and biological nature and outcome of macroprolactinoma and hyperprolactinemia following chronic alcohol intake. There is a succinct summary of modern imaging modalities of pituitary tumours and a comprehensive update on novel medical therapies including chimeric SSTR/D2R compounds. Neurotransmitter modulation of GHRH-GH axis and growth hormone deficiency in adults are lucidly discussed. The book describes the pathogenesis of familial acromegaly and clinically relevant issues in diagnosis and follow up of acromegaly including contentious issues like growth hormone isoforms and IGF-1 assay. Chapters on acromegaly treatment give a comprehensive overview of recent treatment strategies with special emphasis on combination therapy. The chapter on Cushing's syndrome addresses the key issue of diagnosis of cure and long-term follow up with special focus on persistent abnormal body composition, increased cardiovascular risk and poor quality of life. Though there is a comprehensive overview of medical therapy in Cushing's disease, the information is a little outdated. The closing chapter extensively discusses the cross-talk between gut and brain to optimize metabolism with new insights into the role of ghreline in the anterior pituitary function and long appreciated orexigenic effect.

All chapters are written by experts in the field, most of whom are astute clinicians as well as innovators and original researchers. Furthermore this book has a "bench to bedside approach" from basic research to clinical applications. This update on basic and clinical pituitary research is an essential reading for endocrinologists, neuroendocrinologists, neurosurgeons as well as basic researchers, and young scientists to explore new horizons concerning pituitary.




 

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