Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
  Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login  
  Home Print this page Email this page Small font sizeDefault font sizeIncrease font size Users Online: 824       
ORIGINAL ARTICLE
Year : 2014  |  Volume : 139  |  Issue : 2  |  Page : 267-272

Early evaluation of magnetic resonance imaging guided focused ultrasound sonication in the treatment of uterine fibroids


1 Department of Obstetrics & Gynecology, GSL Medical College & General Hospital, Rajahmundry, Andhra Pradesh, India
2 Department of Medicine, GSL Medical College & General Hospital, Rajahmundry, Andhra Pradesh, India
3 Department of Radiology, GSL Medical College & General Hospital, Rajahmundry, Andhra Pradesh, India

Correspondence Address:
Y Himabindu
Associate Professor, Department of Obstetrics & Gynecology GSL Medical College & General Hospital, Rajahmundry 533 296, Andhra Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 24718402

Rights and PermissionsRights and Permissions

Background & objectives: Uterine leiomyomas (fibroids) are common cause of morbidity in women of reproductive age group. High intensity focused ultrasound with the imaging guidance of magnetic resonance imaging (MRI) known as magnetic resonance guided focused ultrasound sonication (MRgFUS) is now available. However, there are no available studies with this non invasive modality of treatment in Indian subjects. The objective of this study was to determine the safety and clinical efficacy of MRgFUS in the treatment of uterine fibroids. Methods: This prospective study included 32 consecutive women with clinically symptomatic uterine fibroids who were treated with MRgFUS from February 2011 to October 2011. Pre and post treatment symptom severity scores (SSS) were assessed at the time of enrolment and at one, three and six months follow up using a validated uterine fibroid symptom - quality of life questionnaire (UFS-QOL). Pre and post treatment fibroid volumes were compared immediately after treatment and at six months follow up using contrast enhanced MRI scan. Non perfused volume (NPV) ratios were calculated and correlated with fibroid volume reductions immediately after the treatment and at the end of six months follow up. Results: This procedure was well tolerated by the patients and procedure related adverse effects were non significant. Significant reductions in SSS were seen at one, three and six month intervals after the treatment (P<0.01). Significant reductions were noticed in fibroid volumes at six months follow up compared to pretreatment fibroid volumes (P<0.01). Significant positive correlations were observed between NPV ratios and reduction in fibroid volumes at six months follow-up (r=0.659, P<0.01). Interpretation & conclusions: MRgFUS is relatively a safe and effective non invasive treatment modality for treating uterine fibroids in selected patients. Its long term efficacy is yet to be tested and compared with other available minimally invasive treatment options.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1121    
    Printed26    
    Emailed0    
    PDF Downloaded328    
    Comments [Add]    

Recommend this journal