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Year : 2013  |  Volume : 138  |  Issue : 6  |  Page : 1020-1021

Honey - A nutrient with medicinal property in reflux oesophagitis

MGM Medical College, Kamothe, Navi Mumbai 410 209, India

Date of Web Publication11-Feb-2014

Correspondence Address:
Mahantayya V Math
MGM Medical College, Kamothe, Navi Mumbai 410 209
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Source of Support: None, Conflict of Interest: None

PMID: 24521651

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How to cite this article:
Math MV, Khadkikar RM, Kattimani YR. Honey - A nutrient with medicinal property in reflux oesophagitis. Indian J Med Res 2013;138:1020-1

How to cite this URL:
Math MV, Khadkikar RM, Kattimani YR. Honey - A nutrient with medicinal property in reflux oesophagitis. Indian J Med Res [serial online] 2013 [cited 2020 Jun 5];138:1020-1. Available from:


We read with interest the article by Singh and colleagues [1] which showed that Ginseng (Panax quinquefolium) ameliorated experimentally induced reflux oesophagitis (RE) in rats in a dose dependent manner. This study shows that the Ginseng offers protection against experimentally induced RE in rats by subsiding the inflammatory responses and oxidative stress. Honey has been used as a nutrient and a medicine since ages [2],[3] , and has cytoprotective function and is also used for wound healing. This is likely to be due to its anti-inflammatory activity and stimulation of local wound responses [4] . Honey has phenolic compounds and flavonoids [5] , and has been used in chronic sinusitis [6] . Antimicrobial activity of honey is due to its osmotic effect [7] . Honey leads to fast healing in patients with oral mucositis [8] and is used in treating otorhinolaryngeal infections [9] .

Oxygen derived free radicals are likely to be mediators in generation of RE [10] . Honey has antioxidant and radical scavenging activity; it reduces intracellular reactive oxygen species (ROS) generation and restores intracellular glutathione [11] . Honey may reduce inflammation by inhibiting nitric oxide and prostaglandin E2 production [12] . Honey has high density, high viscosity, and low surface tension, and therefore, can stay longer in the oesophagus as a coating on the mucus membrane [13],[14],[15] . Honey is useful in treatment of RE because of non peroxide antibacterial activity [16] . Honey can be used in treating reflux oesophagitis along with conventional therapy.

   References Top

1.Singh P, Singh N, Sengupta S, Palit G. Ameliorative effects of Panax quinquefolium on experimentally induced reflux oesophagitis in rats. Indian J Med Res 2012; 135 : 407-13.  Back to cited text no. 1
2.Crane E. History of honey. In: Crane E, editor. Honey, a comprehensive survey. London: William Heinemann; 1975. p. 439-88.  Back to cited text no. 2
3.Jones R. Honey and healing through the ages. In: Munn P, Jones R, editors. Honey and healing, Cardiff: International Bee Research Association; IBRA 2001. p. 49.  Back to cited text no. 3
4.Lusby PE, Coombes A, Wilkinson JM. Honey: a potent agent for wound healing? J Wound Ostomy Continence Nurs 2002; 29 : 295-300.   Back to cited text no. 4
5.Bogdanov S, Jurendic T, Sieber R, Gallmann P. Honey for nutrition and health: a review. J Am Coll Nutr 2008; 27 : 677-89.  Back to cited text no. 5
6.Alandejani T, Marsan J. Ferris W, Slinger R, Chan F. Effectiveness of honey on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. Otolaryngol Head Neck Surg 2009; 141 : 114-8.  Back to cited text no. 6
7.Krell R. Chapter 2 Honey. In value - Added Products from Beekeeping. FAO Agricultural Services Bulletin No.124, FAO United Nations Rome; 1996.  Back to cited text no. 7
8.Abdulrhman M, El Barbary NS, Ahmed Amin D, Saeid Ebrahim R. Honey and a mixture of honey, beeswax, and olive oil-propolis extract in treatment of chemotherapy-induced oral mucositis: a randomized controlled pilot study. Pediatr Hematol Oncol 2012; 29 : 285-92.  Back to cited text no. 8
9.Werner A, Laccourreye O. Honey in otorhinolaryngology: when, why and how? Eur Ann Otorhinolaryngol Head Neck Dis 2011; 128 : 133-7.  Back to cited text no. 9
10.Oh TY, Lee JS, Ahn BO, Cho H, Kim WB, Kim YB, et al. Oxidative damages are critical in pathogenesis of reflux esophagitis: implication of antioxidants in its treatment. Free Radic Biol Med 2001; 30 : 905-15.  Back to cited text no. 10
11.Beretta G, Orioli M, Facino RM. Antioxidant and radical scavenging activity of honey in endothelial cell cultures (EA.hy926). Planta Med 2007; 73 : 1182-9.   Back to cited text no. 11
12.Kassim M, Achoui M, Mansor M, Yusoff KM. The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E(2) in inflammatory tissues. Fitoterapia 2011; 81 : 1196-201.  Back to cited text no. 12
13.Math MV, Balasubramanium P. Viscosity and flow of honey. Indian J Physiol Pharmacol 2001; 45 (Suppl 5): Abstract-76.   Back to cited text no. 13
14.Math MV, Balasubramanium P. Oesophagus; Heart burn and Honey: Rapid Response. BMJ 5 Jan 2002.  Back to cited text no. 14
15.Rehman S, Khan ZF, Maqbool T. Physical and spectroscopic characterization of Pakistani honey. Cien Inv Agr 2008; 35 : 199-204.  Back to cited text no. 15
16.Gear GM. Patent application title: Orally ingestable medicament and method for treating a heartburn inducing event or an acid reflux episode in a living human subject. United States Patent US 20110038945. 2011 Feb. 17.  Back to cited text no. 16


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