Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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REVIEW ARTICLE
Year : 2013  |  Volume : 138  |  Issue : 2  |  Page : 185-193

Obesity & osteoarthritis


1 Sydney Medical School, The University of Sydney, Sydney, Australia
2 Institute of Bone & Joint Research, Kolling Institute of Medical Research, The University of Sydney; Department of Rheumatology, Royal North Shore Hospital, Sydney, Australia
3 Department of Rheumatology, Concord Hospital, Sydney; The University of Sydney, Australia

Correspondence Address:
Ananthila Anandacoomarasamy
Department of Rheumatology, Concord Hospital, Hospital Rd, Concord West, NSW 2138
Australia
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Source of Support: None, Conflict of Interest: None


PMID: 24056594

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The most significant impact of obesity on the musculoskeletal system is associated with osteoarthritis (OA), a disabling degenerative joint disorder characterized by pain, decreased mobility and negative impact on quality of life. OA pathogenesis relates to both excessive joint loading and altered biomechanical patterns together with hormonal and cytokine dysregulation. Obesity is associated with the incidence and progression of OA of both weight-bearing and non weight-bearing joints, to rate of joint replacements as well as operative complications. Weight loss in OA can impart clinically significant improvements in pain and delay progression of joint structural damage. Further work is required to determine the relative contributions of mechanical and metabolic factors in the pathogenesis of OA.


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