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Year : 2013  |  Volume : 137  |  Issue : 6  |  Page : 1052-1060

Hidden magicians of genome evolution


1 Department of Genetics, Osmania University, Hyderabad, India
2 Department of Genetics, Institute of Genetics & Hospital for Genetic Diseases, Hyderabad, India

Correspondence Address:
Pratibha Nallari
Professor, Department of Genetics, Osmania University, Hyderabad 500 007
India
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Source of Support: None, Conflict of Interest: None


PMID: 23852286

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Transposable elements (TEs) represent genome's dynamic component, causing mutations and genetic variations. Transposable elements can invade eukaryotic genomes in a short span; these are silenced by homology-dependent gene silencing and some functional parts of silenced elements are utilized to perform novel cellular functions. However, during the past two decades, major interest has been focused on the positive contribution of these elements in the evolution of genomes. The interaction between mobile DNAs and their host genomes are quite diverse, ranging from modifications of gene structure to alterations in general genome architecture and can be regarded as hidden magicians in shaping evolution of genomes. Some of the prominent examples that impressively demonstrate the beneficial impact of TEs on host biology over evolutionary time include their role in structure and functions of eukaryotic genomes.


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