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REVIEW ARTICLE
Year : 2013  |  Volume : 137  |  Issue : 6  |  Page : 1043-1051

Current concepts in the management of small cell lung cancer


1 Section of Hematology-Oncology, Department of Medicine, VA Nebraska Western Iowa Health Care System; Division of Oncology-Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
2 Department of Pathology-Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
3 Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA

Correspondence Address:
Apar Kishor Ganti
Division of Oncology-Hematology, Department of Internal Medicine, University of Nebraska Medical Center, 987680 Nebraska Medical Center Omaha, NE 68198-7680
USA
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Source of Support: None, Conflict of Interest: None


PMID: 23852285

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Small cell lung cancer (SCLC) has a clinical course that is distinct from its more common counterpart non-small cell lung cancer. SCLC continues to be a major clinical problem, with an aggressive clinical course and short disease-free duration after initial therapy. Current optimal treatment consists of chemotherapy with platinum-etoposide, given concurrently with thoracic irradiation in patients with limited stage disease and chemotherapy alone in those with extensive stage. Prophylactic cranial irradiation (PCI) is recommended for patients who have responded to initial therapy, as it not only decreases the risk of brain metastases and but also improves overall survival. Newer targeted agents are currently being evaluated for this disease.


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