Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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ORIGINAL ARTICLE
Year : 2012  |  Volume : 136  |  Issue : 4  |  Page : 641-648

Resolution of immune response by recombinant transforming growth factor-beta (rTGF-β) during influenza A virus infection


1 Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
2 Department of Pathology, University College of Medical Sciences, University of Delhi, Delhi, India

Correspondence Address:
Madhu Khanna
Associate Professor, Department of Respiratory Virology, V.P. Chest Institute, University of Delhi, Delhi 110 007
India
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Source of Support: None, Conflict of Interest: None


PMID: 23168705

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Background & objectives: Replication of influenza A virus in the respiratory tract leads to cell damage and liberation of cytokines and chemokines. The in vivo cytokine induction and modulation by recombinant transforming growth factor- β1 (rTGF-β1) has not been studied. Therefore, in the present study the effect of rTGF-β1, a potent immunomodulatory cytokine which has anti-inflammatory properties and downregulates the release of inflammatory molecules, against influenza-virus infection in the airway of mice was investigated. Methods: rTGF-β1 was administered intravenously to mice with concomitant intranasal infection of influenza A/Udorn/317/72 (H3N2) virus, and the survival rate, virus titre, histopathological changes and levels of factors regulating inflammation in the airway fluid were analysed. Result: The immune response to influenza A virus was characterized by an influx of both macrophages and lymphocytes into the lungs of the infected host. rTGF-β1 significantly suppressed virus multiplication and improved the survival rate of mice. rTGF-β1 downregulated infiltration of neutrophils and the release of inflammatory molecules, such as interferon-gamma (IFN-γ), interleukin-1 β (IL-1β) and stimulated release of IL-10 that potentiates anti-inflammatory response into airway. Interpretation & conclusions: A generalized pulmonary inflammation does not contribute to viral clearance but represents an immunological background within which antiviral immunity operates. Treatment with rTGF-β1 reduced macrophage count and neutrophils influx in lungs of infected mice.


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