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CORRESPONDENCE
Year : 2012  |  Volume : 136  |  Issue : 2  |  Page : 311

Vitamin D deficiency in hyperthyroidism


Department of Medicine & Endocrinology, Maulana Azad Medical College, New Delhi 110 002, India

Date of Web Publication7-Sep-2012

Correspondence Address:
Dinesh K Dhanwal
Department of Medicine & Endocrinology, Maulana Azad Medical College, New Delhi 110 002
India
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Source of Support: None, Conflict of Interest: None


PMID: 22960905

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How to cite this article:
Dhanwal DK. Vitamin D deficiency in hyperthyroidism. Indian J Med Res 2012;136:311

How to cite this URL:
Dhanwal DK. Vitamin D deficiency in hyperthyroidism. Indian J Med Res [serial online] 2012 [cited 2019 Aug 26];136:311. Available from: http://www.ijmr.org.in/text.asp?2012/136/2/311/100801

Sir,

I read the aricle by Jyotsana et al[1] with interest in which authors have described bone mineral homeostasis in subjects with hyperthyroidism [1] . The most surprising element is lower vitamin D levels in controls compared to patients. Authors have failed to give adequate explanation of this finding. We have reported significantly lower vitamin D levels in Indian patients with hyperthyroidism [2] . In this study, 30 patients with thyrotoxicosis were studied for vitamin D status and bone mineral density (BMD). The mean 25 (OH) vitamin D levels in patient group were 15.3΁7.1 ng/ml and 30 per cent of patients had severe vitamin D deficiency (<10 ng/ml). We have postulated hyperpigmentation of skin, malabsorption and increased vitamin D metabolism as possible mechanisms of vitamin D deficiency in hyperthyroidism [3] . Authors of the present study [1] have not cited this important paper which was first reported study on this subject from India. Goswami et al[4] have reported malabsorption in Indian patients with hyperthyroidism. According to this study significant number of patients (46%) with thyrotoxicosis in India had fat mal- absorption [4] . Absorption of fat soluble vitamins such as vitamin D is likely to be hindered in such a state. It is worthwhile to study correlation between steatorrhea and vitamin D status in these patients with thyrotoxicosis. Also, in [Table 1] mean age in two groups looks similar but has been shown as significantly different. The signs * and ** have not been explained.

 
   References Top

1.Jyotsna VP, Sahoo A, Ksh SA, Sreenivas V, Gupta N. Bone mineral density in patients of Graves disease pre- & post-treatment in a predominantly vitamin D deficient population. Indian J Med Res 2012; 135 : 36-41.  Back to cited text no. 1
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2.Dhanwal DK, Kochupillai N, Gupta N, Cooper C, Dennison EM. Hypovitaminosis D and bone mineral metabolism and bone density in hyperthyroidism. J Clin Densitom 2010; 13 : 462-6.   Back to cited text no. 2
    
3.Banba K, Tanaka N, Fujioka A, Tajima S. Hyperpigmentation caused by hyperthyroidism: differences from the pigmentation of Addison's disease. Clin Exp Dermatol 1999; 24 : 196-8.  Back to cited text no. 3
    
4.Goswami R, Tandon RK, Dudha A, Kochupillai N. Prevalence and significance of steatorrhea in patients with active Graves' disease. Am J Gastroenterol 1998; 93 : 1122-5.  Back to cited text no. 4
    




 

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