| REVIEW ARTICLE |
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| Year : 2012 | Volume
: 135
| Issue : 3 | Page : 277-286 |
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Bone disease in thyrotoxicosis
P Amaresh Reddy, CV Harinarayan, Alok Sachan, V Suresh, G Rajagopal
Department of Endocrinology & Metabolism, Sri Venkateswara Institute of Medical Sciences, Tirupati, India
Correspondence Address:
C V Harinarayan
Professor & Head, Department of Endocrinology & Metabolism, Sri Venkateswara Institute of Medical Sciences, Tirupati 517 507
India
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Thyrotoxicosis, a clinical syndrome characterized by manifestations of excess thyroid hormone, is one of the commonly-recognised conditions of the thyroid gland. Thyrotoxicosis causes acceleration of bone remodelling and though it is one of the known risk factors for osteoporosis, the metabolic effects of thyroxine on bone are not well discussed. Studies show that thyroid hormones have effects on bone, both in vitro and in vivo. Treatment of thyrotoxicosis leads to reversal of bone loss and metabolic alterations, and decreases the fracture risk. There are limited studies in India as to whether these changes are fully reversible. In this review we discuss about the effects of thyrotoxicosis (endogenous and exogenous) on bone and mineral metabolism, effects of subclinical thyrotoxicosis on bone and mineral metabolism and effects of various forms of treatment in improving the bone mineral density in thyrotoxicosis. |
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