Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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REVIEW ARTICLE
Year : 2011  |  Volume : 134  |  Issue : 6  |  Page : 769-778

Genetic architecture of HIV-1 genes circulating in north India & their functional implications


1 Department of Virology, National Institute of Immunology, New Delhi, India
2 Department of Virology, University College of Medical Sciences & GTB Hospital, Delhi, India
3 Department of Virology, Postgraduate Institute of Medical Education & Research, Chandigarh, India

Correspondence Address:
Akhil C Banerjea
Chief & Staff Scientist VII, Laboratory of Virology, National Institute of Immunology, JNU Campus, Aruna Asaf Ali Marg, New Delhi 110 067
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-5916.92624

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This review presents data on genetic and functional analysis of some of the HIV-1 genes derived from HIV-1 infected individuals from north India (Delhi, Punjab and Chandigarh). We found evidence of novel B/C recombinants in HIV-1 LTR region showing relatedness to China/Mynmar with 3 copies of Nfκb sites; B/C/D mosaic genomes for HIV-1 Vpr and novel B/C Tat. We reported appearance of a complex recombinant form CRF_02AG of HIV-1 envelope sequences which is predominantly found in Central/Western Africa. Also one Indian HIV-1 envelope subtype C sequence suggested exclusive CXCR4 co-receptor usage. This extensive recombination, which is observed in about 10 per cent HIV-1 infected individuals in the Vpr genes, resulted in remarkably altered functions when compared with prototype subtype B Vpr. The Vpu C was found to be more potent in causing apoptosis when compared with Vpu B when analyzed for subG1 DNA content. The functional implications of these changes as well as in other genes of HIV-1 are discussed in detail with possible implications for subtype-specific pathogenesis highlighted.


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