|Year : 2011 | Volume
| Issue : 5 | Page : 611-620
Hand hygiene: Back to the basics of infection control
Department of Laboratory Medicine, Jai Prakash Narain Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India
|Date of Submission||13-Jan-2010|
|Date of Web Publication||20-Dec-2011|
Assistant Professor, Department of Laboratory Medicine, Jai Prakash Narain Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi 110 029
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Health care associated infections are drawing increasing attention from patients, insurers, governments and regulatory bodies. This is not only because of the magnitude of the problem in terms of the associated morbidity, mortality and cost of treatment, but also due to the growing recognition that most of these are preventable. The medical community is witnessing in tandem unprecedented advancements in the understanding of pathophysiology of infectious diseases and the global spread of multi-drug resistant infections in health care set-ups. These factors, compounded by the paucity of availability of new antimicrobials have necessitated a re-look into the role of basic practices of infection prevention in modern day health care. There is now undisputed evidence that strict adherence to hand hygiene reduces the risk of cross-transmission of infections. With "Clean Care is Safer Care" as a prime agenda of the global initiative of WHO on patient safety programmes, it is time for developing countries to formulate the much-needed policies for implementation of basic infection prevention practices in health care set-ups. This review focuses on one of the simplest, low cost but least accepted from infection prevention: hand hygiene.
Keywords: Alcohol-based hand rubs - compliance - hand hygiene - hand hygiene agents - hand washing - India
|How to cite this article:|
Mathur P. Hand hygiene: Back to the basics of infection control. Indian J Med Res 2011;134:611-20
| Introduction|| |
Hand hygiene is now regarded as one of the most important element of infection control activities. In the wake of the growing burden of health care associated infections (HCAIs), the increasing severity of illness and complexity of treatment, superimposed by multi-drug resistant (MDR) pathogen infections, health care practitioners (HCPs) are reversing back to the basics of infection preventions by simple measures like hand hygiene. This is because enough scientific evidence supports the observation that if properly implemented, hand hygiene alone can significantly reduce the risk of cross-transmission of infection in healthcare facilities (HCFs) ,,,, .
| Historical Background|| |
The significance of hand washing in patient care was conceptualized in the early 19 th century ,, . Labarraque  provided the first evidence that hand decontamination can markedly reduce the incidence of puerperal fever and maternal mortality. Semmelweis  worked in the Great hospital in Vienna in the 1840s. There were two maternity clinics in the hospital, with alternate day admission policy. The first clinic was attended by medical students, who moved straight from autopsy rooms to the delivery suite and had an average maternal mortality rate due to puerperal fever of about 10 per cent. The second clinic, attended by midwives had a maternal mortality of only 2 per cent. The puzzled Semmelweis got a breakthrough in 1847, following the death of colleague Jokob Kolletschka, who had been accidentally got a cut by a student's scalpel while performing an autopsy. His autopsy showed a pathological condition similar to that of women drying from puerperal fever. Semmelweis concluded that some "unknown cadaverous material" caused puerperal fever. He instituted a policy of washing hands with chlorinted lime for those leaving the autopsy room, following which the rate of maternal mortality dropped ten-folds, comparable to the second clinic. Thus, he almost conducted a controlled trial, in an era when microbes were yet to be discovered and the germ theory of disease was not defined ,, . In another landmark study in the wake of Staphylococcal epidemics in 1950s, Mortimer et al showed that direct contact was the main mode of transmission of S. aureus in nurseries. They also demonstrated that hand washing by patients' contacts reduced the level of S. aureus acquisition by babies.
In 1975 and 1985, the CDC published guidelines on hand washing practices in hospitals, primarily advocating hand washing with non antimicrobial soaps; washing with antimicrobial soap was advised before and after performing invasive procedures or during care for high risk patients. Alcohol-based solutions were recommended only in situations where sinks were not available , . In 1995, the Hospital Infection Control Practices Advisory Committee (HICPAC) advocated the use of antimicrobial soap or a waterless antiseptic agent for cleaning hands upon leaving the rooms of patients infected with multidrug-resistant pathogens  . In 2002, the CDC published revised guidelines for hand hygiene  . A major change in these guidelines was the recommendation to use alcohol based hand rubs for decontamination of hands between each patient contact (of non-soiling type) and the use of liquid soap and water for cleaning visibly contaminated or soiled hands. A systematic review of handwashing by the Thames Valley University as part of the evaluation of processes and indicators in infection control (EPIC) study  , concluded that there was a good evidence that direct patient contact resulted in hand contamination by pathogens. The EPIC study also showed the superiority of 70 per cent alcohol/ alcohol based antiseptic hand rubs , .
With the growing burden of HAIs, limited options of effective antimicrobials evidence supporting the role of hand hygiene in reduction of HAIs, the WHO has launched a global hand hygiene campaign. In 2005, it introduced the first Global Patient Safety Challenge "Clean Care is Safer Care (CCiSC)", as part of its world alliance for patient safety , . In 2006, advanced draft guidelines on "Hand Hygiene in Health Care" were published and a suite of implementation tools were developed and tested  . The first Global Handwashing Day was observed on October 15, 2008. A WHO Patient Safety 2009 initiative has been established to catalyse this progress. This is the next phase of the 'First Challenge's work on CCiSC' ,,, . This initiative has, as of April 2009, seen a total of 3,863 health care facilities registering their commitment, effectively equating to a staff of over 3.6 million people, globally. On May 5, 2009, the WHO highlighted the importance of hand hygiene and launched guidelines and tools on hand hygiene, based on the next phase of patient safety work programme "SAVE LIVES: Clean Your Hands" ,,,,, .
| Normal Flora of Hands|| |
There are two types of microbes colonizing hands: the resident flora, which consists of microorganisms residing under the superficial cells of the stratum corneum and the transient flora, which colonizes the superficial layers of the skin, and is more amenable to removal by routine hand hygiene. Transient microorganisms survive, but do not usually multiply on the skin. They are often acquired by health care workers (HCWs) during direct contact with patients or their nearby contaminated environmental surfaces and are the organisms most frequently associated with HCAIs ,, .
| Colonization of Hands with Pathogens and their role in Transmission|| |
The hands of HCWs are commonly colonized with pathogens like methicillin resistant S. aureus (MRSA), vancomycin resistant Enterococcus (VRE), MDR-Gram Negative bacteria (GNBs), Candida spp. and Clostridium difficle, which can survive for as long as 150 h. Approximately 10  skin epithelial cells containing viable microorganisms are shed daily from the normal skin , , which can contaminate the gowns, bed linen, bedside furniture, and other objects in the patient's immediate environment. Hand carriage of resistant pathogens has repeatedly been shown to be associated with nosocomial infections ,, . The highest rates of hand contamination are reported from critical care areas, which also report most cases of cross-transmission. The hands may become contaminated by merely touching the patent's intact skin or inanimate objects in patients' rooms or during the "clean" procedures like recording blood pressure ,, .
| Importance of Hand Hygiene|| |
Proper hand hygiene is the single most important, simplest, and least expensive means of reducing the prevalence of HAIs and the spread of antimicrobial resistance ,,,,,, . Several studies have demonstrated that handwashing virtally eradicates the carriage of MRSA which invariably occurs on the hands of HCPs working in ICUs , . An increase in handwashing compliance has been found to be accompanied by a fall in MRSA rates  . The hand hygiene liason group identified nine controlled studies, all of which showed significant reductions in infection related outcomes, even in settings with a high infection rates in critically ill patients ,, . Transmission of Health-care-associated Klebsiella sp. has also been documented to reduce with improvement in hand hygiene ,, . The evidence suggests that adherence to hand hygiene practices has significantly reduced the rates of acquisition of pathogens on hands and has ultimately reduced the rates of HAIs in a hospital ,,,,, .
| Indications for Hand Hygiene during Patient Care|| |
Wash hands with soap and water when (i) visibly dirty or contaminated with proteinaceous material, blood, or other body fluids and if exposure to Bacillus anthracis is suspected or proven (since the physical action of washing and rinsing hands in such circumstances is recommended because alcohols, chlorhexidine, iodophors, and other antiseptic agents have poor activity against spores); (ii) After using a restroom, wash hands with a non-antimicrobial soap and water or with an antimicrobial soap and water; and (iii) before and after having food ,,,,,, .
In all other clinical situations described below, when hands are not visibly soiled, an alcohol-based hand rub should be used routinely for decontaminating hands ,,,,,, . (i) Before having direct contact with patients. (ii) Before donning sterile gloves when inserting a central intravascular catheter. (iii) Before inserting indwelling urinary catheters, peripheral vascular catheters, or other invasive devices that do not require a surgical procedure. (iv) After contact with a patient's intact skin (e.g., when taking a pulse or blood pressure or lifting a patient). (v) After contact with body fluids or excretions, mucous membranes, nonintact skin, and wound dressings if hands are not visibly soiled. (vi) After contact with inanimate objects (including medical equipment) in the immediate vicinity of the patient. (vii) After removing gloves. (viii) If moving from a contaminated body site to a clean body site during patient care.
The WHO "SAVE LIVES: Clean Your Hands" programme , reinforces the "My 5 Moments for Hand Hygiene" approach as key to protect the patients, HCWs and the health-care environment against the spread of pathogens and thus reduce HAIs. This approach encourages HCWs to clean their hands: before touching a patient, before clean/aseptic procedures, after body fluid exposure/risk, after touching a patient and after touching patient surroundings , .
| Other Precautions in Relation to Hand Sanitation|| |
Avoid unnecessary touching of surfaces in close proximity to the patient. In 2002, the CDC/HICPAC recommended that artificial fingernails and extenders not to be worn by HCPs who have contact with high-risk patients, due to their association with outbreaks of Gram-negative bacillary and candidal infections  . Although rings harbour a high count of pathogens, they have not been found to be associated with transmission of infections  .
| Method of Hand Washing|| |
For handwashing, remove the jewelry and rinse hands under running water (preferably warm). Lather with soap and using friction, cover all surfaces of hands and fingers. Wash thoroughly under running water. Turn off faucet with wrist/elbow. Dry hands with a single use towel or by using forced air drying. Pat skin rather than rubbing to avoid cracking. If disposable towels are used, throw in trash immediately. Skin excoriation may lead to bacteria colonizing the skin and the possible spread of blood borne viruses as well as other microorganisms. Sore hands may also lead to decreased compliance with hand washing protocols ,, . If using antiseptic rub, take an adequate amount and rub on all surfaces for the recommended time. Let the antiseptic dry on its own.
| Agents Used for Hand Hygiene|| |
[Table 1] lists the properties, advantages and disadvantages of the commonly used agents for hand hygiene ,,,,, .
| Selecting Hand Hygiene Products for Health Set-Ups|| |
The major determinants for product selection are antimicrobial profile, user acceptance, and cost ,, . Post-contamination hand hygiene products must have at least bactericidal, fungicidal (yeasts), and virucidal (coated viruses) activity. Since hands of HCWs are frequently contaminated with blood during routine patient care, activity against coated viruses should be included in the minimum spectrum of activity of an agent for hand hygiene  . Additional activity against fungi (including molds), mycobacteria, and bacterial spores may be relevant in high risk wards or during outbreaks. Pre-operative hand hygiene should be at least bactericidal and fungicidal (yeasts), since the hands of most HCWs carry yeasts and surgical- site infections have also been associated with hand carriage of yeasts during an outbreak  .
Hospital administrators should also take into account the acceptability of product (smell, feel, skin irritation) by the users and its allergenic potential ,,,, . When comparing the cost of hand hygiene products, it has been found that the excess hospital cost associated with only 4-5 HAIs of average severity may equal the entire annual budget for hand hygiene products used for in-patient care areas , .
One of the key elements in improving hand hygiene practice is the use of an alcohol based hand rub instead of washing with soap and water. An alcohol-based hand rub requires less time, is microbiologically more effective and is less irritating to skin than traditional hand washing with soap and water ,, . In the ICUs, switching to alcohol hand disinfection would decrease the time necessary for hand hygiene from 1.3 h (or 17% of total nursing time) to 0.3 h (or 4% of total nursing time) , .
| Reasons for Poor Hand Hygiene Practices|| |
In most health care institutions, adherence to recommended hand-washing practices remains unacceptably low, rarely exceeding 40 per cent of situations in which hand hygiene is indicated , . Hand hygiene reflects attitudes, behaviours and beliefs. Some of the observed/self reported factors found to be affecting hand hygiene behaviours are enlisted in [Table 2] ,,,,,.
| Methods used to Improve Hand Hygiene Compliance|| |
Multimodal strategies have been shown to be more successful in improving rates of adherence with hand hygiene in HCWs than single interventions  . Targeted, multi-faceted approaches focusing on system change, administrative support, motivation, availability of alcohol-based hand rubs, training and intensive education of HCWs and reminders in the workplace have been recommended for improvement in hand hygiene  .
Recent studies support the fact that interactive educational programmes combined with free availability of hand disinfectants significantly increased the hand hygiene compliance , . A single lecture on basic hand hygiene protocols had a significant and sustained effect in enhancing hand hygiene compliance in a Swedish hospital  . The four member States of the European Union, which implemented National Hand Hygiene Campaigns found the following strategies to be extremely useful in their countries: Governmental support, the use of indicators for hand hygiene benchmarking, developing national surveillance systems for auditing alcohol based hand rub consumption and auditing hand hygiene compliance  . Trampuz et al advocated simple training sessions for HCWs to be held in each ward to introduce the advantage of alcohol hand rubs over hand washing.
Other factors like positive role modeling (hand hygiene behaviour of senior practitioners) and the use of performance indicators also remarkably improve adherence to hand hygiene , . There should be adequate supply of hand hygiene products, lotions and creams, disposable towels and facilities for hand washing, where necessary ,,,,, . Alcohol hand rubs should be available at the point of care in sufficient quantities. It needs to be emphasized that wearing gloves does not replace the need for hand hygiene and that contamination may occur during glove removal. Studies by Pitet , showed a remarkable and long lasting improvement in hand hygiene compliance using a multimodal strategy, which has been adopted by the first Global Patient Safety Challenge of WHO to develop hand hygiene strategies. The availability of individual, pocket carried bottles also increased compliance ,,,,, .
Apart from this, all hospitals should have a dynamic infection control team, robust surveillance system, adequate staff to disseminate evidence-based knowledge in an easily comprehensible way to all cadres of staff. At a more local or regional level, there is a need for institutional frameworks or programmes to deal with HAIs  . The Institute for Healthcare Improvement (www.ihi.org) offers elaborate training modules on various aspects of patient care. The guide for implementation of WHO's CCiSC and a range of tools to facilitate hand hygiene is available  .
| Research and Education|| |
To develop successful interventions, more research into behavioural determinants is needed, in particular, how these determinants can be applied to improve hand hygiene , . Process indicators are vital and an understanding of why some interventions succeed and others fail is needed. Since hand hygiene is more of a behavioural practice, the first step towards the development of interventions should be to identify the prevalence of risk behaviours (i.e. non compliance) and the difference in risk behaviours. Since the reasons for non-compliance vary among countries, large scale systematic studies are needed to identify the reasons thereof and plan remedial strategies.
An expert panel has recommended that measuring hand hygiene compliance is essential to understand the current situation, facilitate change and to measure the impact of interventions  . This can be done by direct observation, automated electronic monitoring, product consumption and self reporting by HCW  .
The important aspect of role models for students, whose adherence is strongly influenced by their mentor's attitude at bed side should be exploited in moulding the behaviour of young medical students. A few lectures in the undergraduate curriculum may prime the medical students to this basic necessity. The Hand Hygiene Liason Group strongly advocates teaching of elementary hygiene practices at medical schools  . In an elaborate study focusing on MBBS students, it was noted that assessing the knowledge, attitude and practices of final year MBBS students and providing a positive role modeling at undergraduate level is a good initiative  .
| Indian Scenario|| |
In India, the quality of healthcare is governed by various factors, the principal amongst these being whether the health care organization is government or private-sector run. There is also an economic and regional disparity throughout the country. About 75 per cent of health infrastructure, medical manpower and other health resources are concentrated in urban areas, where 27 per cent of the population lives  . There is a lack of availability of clean water for drinking and washing. Like in other developing countries, the priority given to prevention and control of HCAI is minimal. This is primarily due to lack of infrastructure, trained manpower, surveillance systems, poor sanitation, overcrowding and understaffing of hospitals, unfavourable social background of population, lack of legislations mandating accreditation of hospitals and a general attitude of non-compliance amongst health care providers towards even basic procedures of infection control. In India, although hand hygiene is imbibed as a custom and promoted at school and community levels to reduce the burden of diarrhoea, there is a paucity of information on activities to promote hand hygiene in HCFs. Sporadic reports document the role of hands in spreading infection and isolated efforts at improving hand hygiene across the country ,,, .
The practice of compulsory training on standard precautions, safe hospital practices and infection control for all postgraduates upon course-induction, as is being done in a few Delhi medical colleges seems very promising for our country. Such an exercise may be made mandatory across all medical and nursing colleges of India, especially since the "patient safety" is increasingly being prioritized by the Government of India and the country being one of the 120 signatories pledging support to the WHO launched world alliance (available at http://www.who.int/patientsafery/events/06/statememts/India_pledge.pdf ).
| Challenges Ahead|| |
Although evidence based guidelines are increasingly being implemented in the developed countries, the developing countries still lack basic health care facilities, surveillance networks and resources to curtail HAIs ,, . Lack of hand washing facilities (e.g., sinks, running water and sewage systems) are major deterrents for implementation of hand hygiene  . The use of WHO advocated alcohol based hand rubs is a practical solution to overcome these constraints, because these can be distributed individually to staff for pocket carriage and placed at the point of care. The major advantage is that its use is well applicable to situations typical of developing countries, such as two patients sharing the same bed, or patient's relatives being requested to help in care provision. Several hospitals are now reporting increased compliance after implementation of CCiSC  . Several countries have also initiated nationally co-ordinated activities (http:// www.who.int/gpsc/national-campaigns/en/) to promote hand hygiene  . However, global Healthcare Infection Prevention programmes can only be successful, if these populous developing nations are able to control the menace by formulation of national or local policies and strictly implementing the guidelines.
| Conclusion|| |
Hand washing should become an educational priority. Educational interventions for medical students should provide clear evidence that HCWs hands become grossly contaminated with pathogens upon patient contact and that alcohol hand rubs are the easiest and most effective means of decontaminating hands and thereby reducing the rates of HAIs. Increasing the emphasis on infection control, giving the charge of infection control to senior organizational members, changing the paradigm of surveillance to continuous monitoring and effective data feedback are some of the important measures which need to be initiated in Indian hospitals.
One of the reasons microbes have survived in nature is probably their simplicity: a simple genomic framework with genetic encryptation of basic survival strategies. To tackle these microbes, human beings will have to follow basic and simple protocols of infection prevention. The health care practitioners in our country need to brace themselves to inculcate the simple, basic and effective practice of hand hygiene in their daily patient care activities and serve as a role model for future generations of doctors, nurses and paramedical personnels.
| References|| |
|1.||Guide to implementation of the WHO multimodal hand hygiene improvement strategy. Available from: http://www.who.int/patientsafety/en/, accessed on August 24, 2010. |
|2.||WHO Guidelines on Hand Hygiene in Health Care. First Global Patient Safety Challenge. Clean Care is Safer Care. Available from: http://www.who.int/patientsafety/en/, accessed on August 24, 2010. |
|3.||Boyce JM, Pittet D. Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Morb Mortal Wkly Rep 2002; 51 : 1-44. |
|4.||Kampf G, Kramer A. Epidemiologic background of Hand Hygiene and evaluation of the most important agents for scrubs and rubs. Clin Microbiol Rev 2004; 17 : 863-93. |
|5.||Daniels IR, Rees BI. Handwashing: simple, but effective. Ann R Coll Surg Engl 1999; 81 : 117-8. |
|6.||Labarraque AG. Instructions and observations regarding the use of the chlorides of soda and lime. In: Porter J, editor. New Haven, CT: Baldwin and Treadway; 1829. |
|7.||Semmelweis I. Etiology, concept, and prophylaxis of childbed fever. In: Carter KC, editor. 1 st ed. Madison, WI: The University of Wisconsin Press; 1983. |
|8.||Rotter ML. 150 years of hand disinfection-Semmelweis' heritage. Hyg Med 1997; 22 : 332-9. |
|9.||Mortimer EA, Wolinsky E, Gonzaga AJ, Remmelkamp CH. Role of airborne transmission in Staphylococcal infections. BMJ 1966; 1 : 319-22. |
|10.||Steere AC, Mallison GF. Handwashing practices for the prevention of nosocomial infections. Ann Intern Med 1975; 83 : 683-90. |
|11.||Garner JS, Favero MS. CDC guideline for handwashing and hospital environmental control, 1985. Infect Control 1986; 7 : 231-43. |
|12.||Hospital Infection Control Practices Advisory Committee (HICPAC). Recommendations for preventing the spread of vancomycin resistance. Infect Control Hosp Epidemiol 1995; 16 : 105-13. |
|13.||Pratt RJ, Pellowe C, Liveday HP, Robinson N, Smith GW, Barrett S. The EPIC project: developing national evidence- based guidelines for preventing healthcare associated infections. J Hosp Infect 2001; 47 (Suppl A): S3-82. |
|14.||Stone SP. Hand hygiene: the case for evidence-based education. J R Soc Med 2001; 94 : 278-81. |
|15.||Allegranzi B, Storr J, Dziekan G, Leotsakos A, Donaldson L, Pittet D. The First Global Patient Safety Challenge "Clean Care is Safer Care": from launch to current progress and achievements. J Hosp Infect 2007; 65 (Suppl 2): 115-23. |
|16.||Magiorakos AP, Suetens C, Boyd L, Costa C. National Hand Hygiene Campaigns in Europe, 2000-2009. Euro Survell 2009; 14 : ii-19191. |
|17.||World Health Organization. WHO guidelines for hand hygiene in health care (Advanced draft). Geneva: WHO; 2006. Available from: http://www.who.int/gpsc/tools/en /, accessed on August 24, 2010. |
|18.||Kilpatrick C , Allegranzi1 B, Pittet D. The global impact of hand hygiene campaigning Euro Survell 2009; 14: p ii-19191. |
|19.||Noble WC. Dispersal of skin microorganisms. Br J Dermatol 1975; 93 : 477-85. |
|20.||Smith SMS. A review of hand-washing techniques in primary care and community settings. J Clin Nurs 2009; 18 : 786-90. |
|21.||Infection control guidelines. Communicable disease report. Canada: Laboratory Centre for Disease Control, Bureau of Infectious Diseases; 1998. |
|22.||Larson E. Skin hygiene and infection prevention: more of the same or different approaches? Clin Infect Dis 1999; 29 : 1287-94. |
|23.||Larson E. A causal link between handwashing and risk of infection? Examination of the evidence. Infect Control Hosp Epidemiol 1988; 9 : 28-36. |
|24.||Peacock JE, Marsick FJ, Wenzel RP. Methicillin resistant Staphylococcus aureus; introduction and spread within a hospital. Ann Intern Med 1980; 93 : 526-32. |
|25.||Thompson RL, Cabezudo I, w0 enzel RP. Epidemiology of nosocomial infection caused by methicillin resistant Staphylococcus aureus. Ann intern Med 1982; 1987 : 309-17. |
|26.||Pitet D. Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Lancet 2000; 356 : 1307-12. |
|27.||Conley JM, Hills S, Ross J, Lertzman J. Handwashing practices in an intensive care unit: the effects of an educational programme and its relationship to infection rates. Am J Infect Control 1989; 17 : 330-9. |
|28.||Khan MU. Interruption of Shigellosis by hand washing. Trans R Soc Med Hyg 1982; 76 : 164-8. |
|29.||Larson EL, Early E, Cloonan P, Sugrue S, Parides M. An organizational climate intervention associated with increased handwashing and decreased nosocomial infections. Behav Med 2000; 26 : 14-22. |
|30.||Mortimer EA Jr, Lipsitz PJ, Wolinsky E, Gonzaga AJ, Rammelkamp CH Jr. Transmission of staphylococci between newborns. Am J Dis Child 1962; 104 : 289-95. |
|31.||Maki DG. The use of antiseptics for handwashing by medical personnel. J Chemother 1989; 1 (Suppl 1): 3-11. |
|32.||Infection control guidelines for the prevention of transmission of infectious diseases in the health care setting. Govt. of Australia: Communicable Diseases Network Australia, the National Public Health Partnership and the Australian Health, Ministers' Advisory Council; January 2004. |
|33.||Widmer AF, Frei R. Decontamination, disinfection and sterilization. In: Pealler MA, editor. The clinical microbiology laboratory in infection detection, prevention and control. USA: ASM Press; 2001. |
|34.||Boyce JM. Antiseptic technology: access, affordability, and acceptance. Emerg Infect Dis 2001; 7 : 231-3. |
|35.||Trampuz A, Widmer AF. Hand hygiene: A frequently missed lifesaving opportunity during patient care. Mayo Clin Proc 2004; 79 : 109-16. |
|36.||Voss A, Widmer AF. No time for handwashing!? Handwashing versus alcoholic rub: can we afford 100% compliance? Infect Control Hosp Epidemiol 1997; 18 : 205-8. |
|37.||Pittet D, Mourouga P, Perneger TV. Compliance with handwashing in a teaching hospital: infection control program. Ann Intern Med 1999; 130 : 126-30. |
|38.||Sax H, Uckay I, Richet H, Aegranzi B, Pittet D. Determinants of good adherence to Hand Hygiene among healthcare workers who have extensive exposure to Hand Hygiene campaigns. Infect Control Hosp Epidemiol 2007; 28 : 1267-74. |
|39.||Erasmus V, Brouwer W, van Beeck Ef, Oenema A, Daha T, Richardus JH. A qualitative exploration of reasons for poor hand hygiene among hospital workers: lack of positive role models and of convincing evidence that hand hygiene prevents cross-infection. Infect Control Hosp Epidemiol 2009; 30 : 415-9. |
|40.||Schneider J, Moromisato D, Zemetra B, Rizziwagner L, Rivero N, Mason W. Hand hygiene adherence is influenced by the behavior of role models. Pediatr Crit Care Med 2009; 10 : 1-5. |
|41.||Pittet D. Improving adherence to hand hygiene practice: A multidisciplinary approach. Emerg Infect Dis 2001; 7 : 234-40. |
|42.||Sjoberg S, Eriksson M. Hand disinfectant practice: the impact of an education intervention. Open Nurs J 2010; 4 : 20-4. |
|43.||Rykkje L, Heggelund A, Harthug S. Improved hand hygiene through simple interventions. Tidsskr Nor Laegeforen 2007; 127 : 861-3. |
|44.||Magiorakos AP, Leens E, Drouvot V, et al. Pathways to clean hands: highlights of successful hand hygiene implementation strategies in Europe. Euro Surveill 2010; 15 : pii=19560. Available from: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19560, accessed on August 24, 2010. |
|45.||Pitet D, et al. Cost implications of successful hand hygiene promotion. Infect Cont Hosp Epidemiol 2004; 25 : 264-6. |
|46.||Erasmus V, Daha TJ, Brug H, et al. Systematic review of studies on compliance with hand hygiene guideline in hospital care. Inf Control Hosp Epidemiol 2010; 31 : 283-94. |
|47.||O'Boyle CA, Henly SJ, Larson E. Understanding adherence to hand hygiene recommendations: the theory of planned behavior. Am J Infect Control 2001; 29 : 352-60. |
|48.||Barrett R, Randle J. Hand hygiene practices: nursing students' perceptions. J Clin Nurs 2008; 17 : 1851-7. |
|49.||Sharma JB, Ahmed GU. Infection control with limited resources: why and how to make it possible. Indian J Med Microbiol 2010; 28 : 11-6. |
|50.||Clean care is safer care. Tools and resources. World Health Organization. http://www.who.int/gpsc/5may/tools/en/index.html. |
|51.||Jumaa PA. Hand hygiene: simple and complex. Int J Infect Dis 2005; 9 : 3-14. |
|52.||Pittet D, Simon A, Hugonnet S, Pessoa-Silva CL, Sauvan V, Perneger TV. Hand hygiene among physicians: performance, beliefs, and perceptions. Ann Intern Med 2004; 141 : 1-8. |
|53.||Consensus management in hand hygiene project expert advisory panel. Measuring hand hygiene adherence: overcoming the challenges. Oakbrook Terrace IL: The joint commission, 2009. http://www.ihi.org/knowledge/Pages/Publications/MeasuringHandHygieneAdherenceOvercomingtheChallenges-appex, accessed on November 4, 2011. |
|54.||Mathai E, Allegranzi B, Kipatrick C, Pittet D. Prevention and control of healthcare associated infections through improved hand hygiene. Indian J Med Microbiol 2010; 28 : 100-6. |
|55.||Handwashing Liason Group. Handwashing a modern measure with big effects. Br Med J 1999; 318 : 686. |
|56.||Feather A, Stone SP, Weisser A, Boursicot KA, Pratt C. Now please wash your hands: the handwashing behaviour of final MBBS candidates. J Hosp Infect 2000; 45 : 62-4. |
|57.||Mani A, Shubhangi AM, Saini R. Hand hygiene among health care workers. Indian J Dent Res 2010; 21 : 115-8. |
|58.||Chandra P, Millind K. Lapses in measures recommended for preventing Hospital acquired infection. J Hosp Infect 2001; 47 : 218-22. |
|59.||Suchitra JB, Lakshmi Devi N. Impact of education on knowledge, attitudes and practices among various categories of healthcare workers on nosocomial infections. Indian J Med Microbiol 2007; 25 : 181-7. |
|60.||Taneja N, Das A, Raman Rao DS, Jain N, Singh M, Sharma M. Nosocomial outbreak of diarrhea by enterotoxigenic E. coli among preterm neonates in a tertiary care hospital in India: pitfalls in healthcare. J Hosp Infect 2003; 53 : 193-7. |
|61.||Pittet D, Allegranzi B, Storr J, Bagheri Nejad S, Dziekan G, Leotsakos A. Infection control as a major World Health Organization priority for developing countries. J Hosp Infect 2008; 68 : 285-92. |
|62.||Raka L. Lowbury Lecture 2008: infection control and limited resources e searching for the best solutions. J Hosp Infect 2009; 72 : 292-8. |
|63.||Pittet D, Donaldson L. Challenging the world: patient safety and health care-associated infection. Int J Qual Health Care 2006; 18 : 4-8. |
|64.||Allegranzi B, Sax H, Bengaly L, Richet H, Minta DK, Chraiti MN. Successful implementation of the World Health Organization hand hygiene improvement strategy in a referral hospital in Mali, Africa. Infect Control Hosp Epidemiol 2010; 31 : 133-41. |
[Table 1], [Table 2]
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|[Pubmed] | [DOI]|
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| ||Issa Ibrahim Abdoulkarim,Bada Alambedji Rianatou,Duprez Jean Noel,Moula Nassim,Bardiau Marjorie,G Mainil Jacques |
| ||African Journal of Microbiology Research. 2015; 9(6): 348 |
|[Pubmed] | [DOI]|
||Predictors of hand hygiene practice among Saudi nursing students: A cross-sectional self-reported study
| ||Jonas Preposi Cruz,Meshrif Ahmad Bashtawi |
| ||Journal of Infection and Public Health. 2015; |
|[Pubmed] | [DOI]|
||Periprocedural Patient Care
| ||Maureen P. Kohi,Nicholas Fidelman,Spencer Behr,Andrew G. Taylor,Kanti Kolli,Miles Conrad,Gloria Hwang,Stefanie Weinstein |
| ||RadioGraphics. 2015; 35(6): 1766 |
|[Pubmed] | [DOI]|
||Tackling antibiotic resistance in India
| ||Chand Wattal,Neeraj Goel |
| ||Expert Review of Anti-infective Therapy. 2014; : 1 |
|[Pubmed] | [DOI]|
||Effect of a behaviour-change intervention on hand washing with soap in India (SuperAmma): A Cluster-Randomised Trial
| ||Joseph L. Mathew,Chandrakant Lahariya,Bhavneet Bharti |
| ||Indian Pediatrics. 2014; 51(5): 393 |
|[Pubmed] | [DOI]|
||Prevention of ventilator-associated pneumonia
| ||J. Oliveira,C. Zagalo,P. Cavaco-Silva |
| ||Revista Portuguesa de Pneumologia. 2014; |
|[Pubmed] | [DOI]|
||How Prepared Are Nigerian Schools for Ebola Virus Disease Prevention and Control?
| ||Adebimpe Wasiu Olalekan,Efuntoye Adeola |
| ||Annals of Global Health. 2014; 80(6): 452 |
|[Pubmed] | [DOI]|
||Iranian healthcare workers’ perspective on hand hygiene: A qualitative study
| ||Mary-Louise McLaws,Saman Farahangiz,Charles J. Palenik,Mehrdad Askarian |
| ||Journal of Infection and Public Health. 2014; |
|[Pubmed] | [DOI]|
||Prevention of ventilator-associated pneumonia
| ||J. Oliveira,C. Zagalo,P. Cavaco-Silva |
| ||Revista Portuguesa de Pneumologia (English Edition). 2014; 20(3): 152 |
|[Pubmed] | [DOI]|
||Strategies to Minimize Antibiotic Resistance
| ||Chang-Ro Lee,Ill Cho,Byeong Jeong,Sang Lee |
| ||International Journal of Environmental Research and Public Health. 2013; 10(9): 4274 |
|[Pubmed] | [DOI]|
||Hand hygiene practices among health care workers (HCWs) in a tertiary care facility in Pune
| ||V. Anargh,Harpreet Singh,Aniket Kulkarni,Atul Kotwal,Ajoy Mahen |
| ||Medical Journal Armed Forces India. 2013; 69(1): 54 |
|[Pubmed] | [DOI]|
||Incidence and factors associated with surgical site infections in a teaching hospital in Ujjain, India
| ||Ashish Pathak,Erika A. Saliba,Shailendra Sharma,Vijay Kumar Mahadik,Harshada Shah,Cecilia Stålsby Lundborg |
| ||American Journal of Infection Control. 2013; |
|[Pubmed] | [DOI]|