Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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REVIEW ARTICLE
Year : 2011  |  Volume : 134  |  Issue : 2  |  Page : 149-161

An understanding of the genetic basis of asthma


1 Department of Studies in Zoology, University of Mysore, Mysore, India
2 Department of Studies in Zoology,J.S.S. Medical College, J.S.S. Hospital, Mysore, India

Correspondence Address:
Nallur B Ramachandra
Human Genetics Laboratory, Department of Studies in Zoology, University of Mysore, Manasagangothri, Mysore 570 006, Karnataka
India
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Source of Support: None, Conflict of Interest: None


PMID: 21911966

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Asthma is the most common chronic childhood disease in developed nations and its prevalence has increased in the world over the last 25 years. It is a complex disease with both genetic and environmental risk factors. Asthma is caused by multiple interacting genes, some having a protective effect and others contributing to the disease pathogenesis, with each gene having its own tendency to be influenced by the environment. This article reviews the current state of the genetics of asthma in six categories, viz. epidemiology, management, aetiology, family and twin studies, segregation and linkage studies, and candidate genes and single nucleotide polymorphisms (SNPs).


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