|Year : 2011 | Volume
| Issue : 3 | Page : 250-252
Vitamin D deficiency in breastfed infants & the need for routine vitamin D supplementation
Kanchi Kamakoti CHILDS Trust Hospital, Chennai 600 034, India
|Date of Web Publication||6-Apr-2011|
Kanchi Kamakoti CHILDS Trust Hospital, Chennai 600 034
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Balasubramanian S. Vitamin D deficiency in breastfed infants & the need for routine vitamin D supplementation. Indian J Med Res 2011;133:250-2
|How to cite this URL:|
Balasubramanian S. Vitamin D deficiency in breastfed infants & the need for routine vitamin D supplementation. Indian J Med Res [serial online] 2011 [cited 2020 Apr 2];133:250-2. Available from: http://www.ijmr.org.in/text.asp?2011/133/3/250/78330
There has been increasing global interest regarding the role of vitamin D in health and disease. In fact, more and more scientific evidence linking vitamin D to various chronic diseases in children and adults is emerging. Prevention of vitamin D deficiency and achieving adequate intake of vitamin D and calcium throughout childhood may reduce the risk of osteoporosis as well as other long-latency disease processes that have been associated with vitamin D-deficiency states in adults ,,, . Despite food fortification policies in many countries and recommendations for vitamin D supplementation of at-risk groups, vitamin D deficiency and infantile rickets remain major public health challenges in many developed and developing countries. There is evidence that the current supplementation recommendations, particularly for pregnant and lactating women, are inadequate to ensure vitamin D sufficiency in these groups.
Rickets attributable to vitamin D deficiency is known to be a condition that is preventable with adequate nutritional intake of vitamin D  . Rickets is an example of extreme vitamin D deficiency, with a peak incidence between 3 and 18 months of age. A state of deficiency occurs months before rickets is obvious on physical examination, and the deficiency state may also present with hypocalcemic seizures  , growth failure, lethargy, irritability, and a predisposition to respiratory infections during infancy  . Two types of presentation of vitamin D deficiency have been described in children  . The first was symptomatic hypocalcemia (including seizures) occurring during periods of rapid growth, with increased metabolic demands, long before any physical findings or radiologic evidence of vitamin D deficiency occurred. The second clinical presentation was that of a more chronic disease, with rickets and/or decreased bone mineralization and either normocalcemia or asymptomatic hypocalcemia.
Historically, the main source of vitamin D has been via synthesis in the skin from cholesterol after exposure to UV-B light. Full-body exposure during summer months for 10 to 15 min in an adult with lighter pigmentation will generate between 10000 and 20000 IU of vitamin D 3 within 24 h; individuals with darker pigmentation require 5 to 10 times more exposure to generate similar amounts of vitamin D3 , .
The amount of UV exposure available for the synthesis of vitamin D depends on many factors other than just time spent outdoors. These factors include the amount of skin pigmentation, body mass, degree of latitude, season, the amount of cloud cover, the extent of air pollution, the amount of skin exposed, and the extent of UV protection, including clothing and sunscreens ,, .
The multitude of factors that affect vitamin D synthesis by the skin  , the most important of which is degree of skin pigmentation, make it difficult to determine what is adequate sunshine exposure for any given infant or child ,. It is still debated as to how much solar UV exposure is appropriate to balance between risks of vitamin D deficiency and skin cancer. This has given rise to the argument that sun avoidance, with a goal of skin cancer prevention, may compromise vitamin D sufficiency. Among dermatologists, there is active discussion about the risks and potential benefits of sun exposure and/or oral vitamin D supplementation . ; however, the vast majority would agree with the current American Academy of Pediatrics guidelines for decreasing sunlight exposure, which include the advice that infants younger than 6 months should be kept out of direct sunlight  .
| Pregnancy, vitamin D, and the foetus|| |
A Cochrane review in 2002  concluded that there are limited data available regarding maternal vitamin D requirements during pregnancy, despite the fact that maternal vitamin D concentrations largely determine the vitamin D status of the foetus and newborn infant. With restricted vitamin D intake and sunlight exposure, maternal deficiency may occur, as has been documented in a number of studies. It is important to note that women with increased skin pigmentation or who have little exposure of their skin to sunlight are at a greater risk of vitamin D deficiency and may need additional vitamin D supplements, especially during pregnancy and lactation  . Adequate nutritional vitamin D status during pregnancy is important for foetal skeletal development, tooth enamel formation, and perhaps general foetal growth and development  . There is some evidence that the vitamin D status of the mother has long-term effects on her infant.
These data suggest that doses exceeding 1000 IU of vitamin D per day are necessary to achieve 25-OH-D concentrations of >50 nmol/l in pregnant women , . The significance of these findings for those who care for the paediatric population is that when a woman who has vitamin D deficiency gives birth, her neonate also will be deficient.
Another study of the intrauterine effect of maternal vitamin D status revealed a significant association between umbilical cord 25-OH-D concentrations and head circumference at 3 and 6 months' postnatal age that persisted after adjustment for confounding factors  . A United Kingdom study demonstrated that higher maternal vitamin D status during pregnancy was associated with improved bone-mineral content and bone mass in children at 9 yr of age  .
| Vitamin D deficiency and breastfeeding|| |
Infants who are exclusively breastfed but who do not receive supplemental vitamin D or adequate sunlight exposure are at increased risk of developing vitamin D deficiency and/or rickets , . Infants with darker pigmentation are at greater risk of vitamin D deficiency, a fact explained by the greater risk of deficiency at birth  and the decreased vitamin D content in milk from women who themselves are deficient.
Although vitamin D concentrations can be increased in milk of lactating women by using large vitamin D supplements, such high-dose supplementation studies in lactating women have not been validated and demonstrated to be safe in larger, more representative populations of women across various parts of the world. Recommendations to universally supplement breastfeeding mothers with high-dose vitamin D cannot be made at this time. Therefore, supplements given to the infant are necessary.
In this issue, Jain and colleagues from New Delhi  have reported their significant observations on the prevalence of vitamin D deficiency and insufficiency [serum 25 hydroxyvitamin D (25OHD) < 15 ng/ml and 15-20 ng/ml, respectively] among healthy term breastfed 3 month-old infants and their mothers. At the present time, however, consensus has not been reached with regard to the concentration of 25OH-D to define vitamin D insufficiency for infants and children  . They have reported extremely high figures of vitamin D deficiency and insufficiency in the infants studied similar to earlier reports from other parts of India. Interestingly radiological rickets was also observed in their study amongst nearly one third of breastfed infants with vitamin D levels <10 ng/ml. Intake of vitamin supplement by the infant, sunlight exposure and maternal 25OH-D levels were found to have positive correlation with the infants' 25OH-D. These findings suggest that hypovitaminosis D could be prevented by adopting maternal supplementation or increasing sunlight exposure for pregnant and lactating mother or by vitamin D supplementation to all infants routinely.
Although it is clear and incontrovertible that human milk is the best nutritive substance for infants during the first year, there has been concern about the adequacy of human milk in providing vitamin D. No one likes to attack breast milk and baby friendly paediatricians are concerned about the issues around 'knocking' breast milk and the suggestion that it is somehow inadequate to meet the needs of the newborn and young infants. However, it has been demonstrated over and over again that breast milk has very low levels of vitamin D which is significant for newborns with a vitamin D deficiency and for those who are exclusively breastfed for a prolonged period of time.
Considering the magnitude of the problem of hypovitaminosis D in infancy, there are several practical difficulties in ensuring adequate sunlight exposure to women and young infants which will involve massive health education campaigns. Added to this is the fear of increasing the risk of malignancies of the skin due to increase in ultraviolet radiation. Changing lifestyles, urbanization, cultural and religious beliefs limiting sunlight exposure due to covered clothing add to the difficulties in ensuring adequate sunlight exposure across populations. There is no consensus on the dosage of vitamin D that needs to be supplemented to pregnant women nor is there robust scientific evidence to support implementation of a vitamin D supplementation programme for pregnant and lactating mothers. The only practical option available is to seriously consider a routine vitamin D supplementation programme starting from neonatal period extending right through the childhood into adolescence. In a recently published study, oral vitamin D 3 supplementation as an oil emulsion has been shown to be associated with significant and sustained increases in 25(OH)D from baseline in fully breastfeeding infants through 7 months  .
| References|| |
|1.||Willer CJ, Dyment DA, Sadovnick AD, Rothwell PM, Murray TJ, Ebers GC. Timing of birth and risk of multiple sclerosis: population based study. BMJ 2005; 330 : 120-4. |
|2.||Kamen DL, Cooper GS, Bouali H, Shaftman SR, Hollis BW, Gilkeson GS. Vitamin D deficiency in systemic lupus erythematosus. Autoimmun Rev 2006; 5 : 114-7. |
|3.||Garland CF, Comstock GW, Garland FC, Helsing KJ, Shaw EK, Gorham ED. Serum 25(OH)D and colon cancer: eight-year prospective study. Lancet 1989; 2 : 1176-8. |
|4.||Giovannucci E, Liu Y, Rimm EB, Hollis BW, Fuchs CS, Stampfer MJ, et al. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst 2006; 98 : 451-9. |
|5.||Thacher TD, Fischer PR, Strand MA, Pettifor JM. Nutritional rickets around the world: causes and future directions. Ann Trop Paediatr 2006; 26 : 1-18. |
|6.||Hatun S, Ozkan B, Orbak Z, Doneray H, Cizmecioglu F, Toprak D, et al. vitamin D deficiency in early infancy. J Nutr 2005; 135 : 279-82. |
|7.||Najada AS, Habashneh MS, Khader M. The frequency of nutritional rickets among hospitalized infants and its relation to respiratory diseases. J Trop Pediatr 2004; 50 : 364-8. |
|8.||Ladhani S, Srinivasan L, Buchanan C, Allgrove J. Presentation of vitamin D deficiency. Arch Dis Child 2004; 89 : 781-4. |
|9.||Matsuoka LY, Wortsman J, Haddad JG, Kolm P, Hollis BW. Racial pigmentation and the cutaneous synthesis of vitamin D. Arch Dermatol 1991; 127 : 536-8. |
|10.||Matsuoka LY, Wortsman J, Hollis BW. Suntanning and cutaneous synthesis of vitamin D 3 . J Lab Clin Med 1990; 116 : 87-90. |
|11.||Matsuoka LY, Wortsman J, Haddad JG, Kolm P, Hollis BW. Racial pigmentation and the cutaneous synthesis of vitamin D. Arch Dermatol 1991; 127 : 536-8. |
|12.||Matsuoka LY, Wortsman J, Dannenberg MJ, Hollis BW, Lu Z, Holick MF. Clothing prevents ultraviolet-B-radiation-dependent photosynthesis of vitamin D 3 . J Clin Endocrinol Metab 1992; 75 : 1099-103. |
|13.||Matsuoka LY, Wortsman J, Hollis BW. Use of topical sunscreen for the evaluation of regional synthesis of vitamin D 3 . J Am Acad Dermatol 1990; 22 : 772-5. |
|14.||Webb AR. Who, what, where and when: influences on cutaneous vitamin D synthesis. Prog Biophys Mol Biol 2006; 92 : 17-25. |
|15.||Grant WB, Garland C, Holick MF. Comparisons of estimated economic burdens due to insufficient solar ultraviolet irradiance and vitamin D and excess solar UV irradiance for the United States. Photochem Photobiol 2005; 81 : 1276-86. |
|16.||Reichrath J. The challenge resulting from positive and negative effects of sunlight: how much solar UV exposure is appropriate to balance between risks of vitamin D deficiency and skin cancer? Prog Biophys Mol Biol 2006; 92 : 9-16. |
|17.||Wagner CL, Greer FR. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. American Academy of Pediatrics Section on Breastfeeding; American Academy of Pediatrics Committee on Nutrition. Pediatrics 2008; 122 : 1142-52. |
|18.||Mahomed K, Gulmezoglu AM. Vitamin D supplementation in pregnancy. In: The Cochrane Library. Oxford, United Kingdom: Update Software; 2002. |
|19.||Hollis BW, Wagner CL. Assessment of dietary vitamin D requirements during pregnancy and lactation. Am J Clin Nutr 2004; 79 : 717-26. |
|20.||Moncrieff M, Fadahunsi TO. Congenital rickets due to maternal vitamin D deficiency. Arch Dis Child 1974; 49 : 810-1. |
|21.||Markestad T, Aksnes L, Ulstein M, Aarskog D. 25-Hydroxyvitamin D and 1,25-dihydroxy vitamin D of D 2 and D 3 origin in maternal and umbilical cord serum after vitamin D 2 supplementation in human pregnancy. Am J Clin Nutr 1984; 40 : 1057-63. |
|22.||Hollis BW, Pittard WB. Evaluation of the total fetomaternal vitamin D relationships at term: evidence for racial differences. J Clin Endocrinol Metab 1984; 59 : 652-6. |
|23.||Brooke OG, Butters F, Wood C. Intrauterine vitamin D nutrition and postnatal growth in Asian infants. Br Med J (Clin Res Ed) 1981; 283 : 1024. |
|24.||Javaid MK, Crozier SR, Harvey NC, Gale CR, Deninison EM, Boucher BJ, et al. Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study [published correction appears in Lancet 2006; 367 : 1486]. Lancet 2006; 367 : 36-43. |
|25.||Kreiter SR, Schwartz RP, Kirkman HN, Charlton PA, Calikoglu AS, Davenport ML. Nutritional rickets in African American breast-fed infants. J Pediatr 2000; 137 : 153-7. |
|26.||Daaboul J, Sanderson S, Kristensen K, Kitson H. Vitamin D deficiency in pregnant and breast-feeding women and their infants. J Perinatol 1997; 17 : 10-4. |
|27.||Basile LA, Taylor SN, Wagner CL, Quinones L, Hollis BW. Neonatal vitamin D status at birth at latitude 32 degrees 72': evidence of deficiency. J Perinatol 2007; 27 : 568-71. |
|28.||Jain V, Gupta N, Kalaivani M, Jain A, s0 inha A, Agarwal R. Vitamin D deficiency in healthy breastfed term infants at 3 months & their mothers in India: s0 easonal variation & determinants. Indian J Med Res 2011; 133 : 267-73. |
|29.||Hollis BW, Wagner CL, Drezner MK, Binkley NC. Circulating vitamin D 3 and 25-hydroxyvitamin D in humans: an important tool to define adequate nutritional vitamin D status. J Steroid Biochem Mol Biol 2007; 103 : 631-63. |
|30.||Wagner CL, Howard C, Hulsey TC, Lawrence RA, Taylor SN, Will H, et al. Circulating 25-hydroxyvitamin d0 levels in fully breastfed infants on oral vitamin d0 supplementation. Int J Endocrinol 2010 (in press) doi: 10.1155/2010/235035. |